Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gna12tm1Citb
Name:	guanine nucleotide binding protein, alpha 12; targeted mutation 1, California Institute of Technology - Biology
MGI ID:	MGI:2183606
Synonyms:	Galpha12-, Gna12-
Gene:	Gna12  Location: Chr5:140745699-140816186 bp, - strand  Genetic Position: Chr5, 79.3 cM
Alliance:	Gna12tm1Citb page

Germline Transmission:	Earliest citation of germline transmission: J:77728
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Approximately one-third of the coding sequence was replaced with a neomycin selection cassette into exon 4. A trunctated transcript was identified in homozygous mutant mice by Northern blot and RT-PCR analyses. Western blot analysis, using antibodies directed against the amino and carboxy termini, showed the absence of protein. (J:77728)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gna12 Mutation:	21 strains or lines available

Original:	J:77728 Gu JL, et al., Interaction of G alpha(12) with G alpha(13) and G alpha(q) signaling pathways. Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9352-7
All:	38 reference(s)