Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol: Ece2tm1Ywa Name: endothelin converting enzyme 2; targeted mutation 1, Masashi Yanagisawa MGI ID: MGI:2181668 Synonyms: ECE-2- Gene: Ece2  Location: Chr16:20448601-20464665 bp, + strand  Genetic Position: Chr16, 12.48 cM, cytoband B1 Alliance: Ece2tm1Ywa page

Cardiac defects in Ece1tm1Reh/Ece1tm1Reh and Ece1tm1Reh/Ece1tm1Reh Ece2tm1Ywa/Ece2tm1Ywa embryos Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:62261
Parent Cell Line:	SM1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 14 and 15, the latter of which encodes the essential conserved zinc-binding motif, were replaced with a neomycin selection cassette. RT-PCR analysis of total RNA extracted from homozygous mutant brain tissue showed an absence of expression. (J:62261)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

4 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Ece2 Mutation:	29 strains or lines available

Original:	J:62261 Yanagisawa H, et al., Disruption of ECE-1 and ECE-2 reveals a role for endothelin-converting enzyme-2 in murine cardiac development. J Clin Invest. 2000 May;105(10):1373-82
All:	7 reference(s)