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Lumtm1Wwk
Targeted Allele Detail
Summary
Symbol: Lumtm1Wwk
Name: lumican; targeted mutation 1, Winston W Y Kao
MGI ID: MGI:2181377
Synonyms: lum-, Lum-
Gene: Lum  Location: Chr10:97401363-97408565 bp, + strand  Genetic Position: Chr10, 50.32 cM
Alliance: Lumtm1Wwk page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:60203
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by replacement of 481 bp of exon 2 with a PGK-hprt cassette (in the opposite orientation) via homologous recombination. Northern blot, in situ hybridization, and immunohistochemistry confirmed the absence of mRNA and protein expression in eyes of homozygous mutant animals. (J:60203)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lum Mutation:  20 strains or lines available
References
Original:  J:60203 Saika S, et al., Role of lumican in the corneal epithelium during wound healing. J Biol Chem. 2000 Jan 28;275(4):2607-12
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory