Phenotypes associated with this allele

• Allele Symbol: Lum^tm1Wwk
• Allele Name: targeted mutation 1, Winston W Y Kao
• Allele ID: MGI:2181377
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lum^tm1Wwk/Lum^tm1Wwk	involves: 129P2/OlaHsd	MGI:3852184
hm2	Lum^tm1Wwk/Lum^tm1Wwk	involves: 129P2/OlaHsd * C57BL/6J	MGI:3852169

Genotype
MGI:3852184

hm1

• Allelic Composition: Lum^tm1Wwk/Lum^tm1Wwk
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

decreased cornea thickness ( J:128992 )

cornea opacity ( J:128992 )

• corneal haze is increased following LPS-induced inflammation unlike in wild-type mice

immune system

decreased neutrophil cell number ( J:128992 )

• the number of neutrophils in LPS-treated corneas is decreased compared to in similarly treated wild-type mice

• however, CXC chemokine production is normal

abnormal inflammatory response ( J:128992 )

• following lethal irradiation and transplantation of EGFP+ cells, infiltration of bone marrow-derived inflammatory cells into LPS treated corneas is reduced compared to in similarly treated wild-type mice

hematopoietic system

decreased neutrophil cell number ( J:128992 )

• the number of neutrophils in LPS-treated corneas is decreased compared to in similarly treated wild-type mice

• however, CXC chemokine production is normal

Genotype
MGI:3852169

hm2

• Allelic Composition: Lum^tm1Wwk/Lum^tm1Wwk
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

reproductive system

reduced male fertility ( J:60203 )

♂ • male mice produce smaller litters than female mice

vision/eye

abnormal cornea wound healing ( J:60203 )

• one day after injury, corneal wound healing is reduced compared to in heterozygous mice

abnormal cornea posterior stroma morphology ( J:60203 )

• contains abnormally thick collagen fibers at 4 months compared to in wild-type mice

cornea opacity ( J:60203 )

• corneal haze

homeostasis/metabolism

abnormal cornea wound healing ( J:60203 )

• one day after injury, corneal wound healing is reduced compared to in heterozygous mice

delayed wound healing ( J:60203 )

• corneal injuries heal after 5 days compared to 3 days for heterozygous mice

integument

abnormal coat appearance ( J:60203 )

• the back skin hairs of adult mice are disarranged unlike in wild-type mice

abnormal skin condition ( J:60203 )

• fragile