Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Cd1d1tm1Luc
Name:	CD1d1 antigen; targeted mutation 1, Luc Van Kaer
MGI ID:	MGI:2180711
Synonyms:	CD1-, cD1d-, CD1d0, CD1d1-, CD1d10
Gene:	Cd1d1  Location: Chr3:86903141-86906748 bp, - strand  Genetic Position: Chr3, 37.91 cM
Alliance:	Cd1d1tm1Luc page

Germline Transmission:	Earliest citation of germline transmission: J:39748
Parent Cell Line:	TL1/TL-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: A neomycin selection cassette replaced 200 nucleotides in exon 3 of Cd1d1, while leaving the adjacent Cd1d2 locus intact. Thymocytes derived from homozygous mutant mice were shown to lack protein surface expression. This finding was confirmed by the inability of a specific hybridoma to recognize thymocytes from homozygous mutant mice. (J:39748)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

List all tumor models in MMHCdb carrying Cd1d1tm1Luc

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Cd1d1 Mutation:	30 strains or lines available

Original:	J:39748 Mendiratta SK, et al., CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4. Immunity. 1997 APR;6(4):469-477
All:	134 reference(s)