Summary | Mutation origin | Mutation description | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Cblbtm1Hua
Name:	Casitas B-lineage lymphoma b; targeted mutation 1, Hua Gu
MGI ID:	MGI:2180572
Synonyms:	Cbl-b-, Cblb-, Cblbdel
Gene:	Cblb  Location: Chr16:51851593-52028410 bp, + strand  Genetic Position: Chr16, 32.88 cM
Alliance:	Cblbtm1Hua page

Germline Transmission:	Earliest citation of germline transmission: J:76897
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neomycin selection gene was inserted into exon 3 immediately downstream of the translation start codon. RT-PCR showed an absence of transcript in homozygous mutant mice while Western analysis further confirmed the abrogation by revealing a lack of protein expression. (J:76897)

View phenotypes and curated references for all genotypes (concatenated display).

List all tumor models in MMHCdb carrying Cblbtm1Hua

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cblb Mutation:	56 strains or lines available

Original:	J:76897 Chiang YJ, et al., Cbl-b regulates the CD28 dependence of T-cell activation. Nature. 2000 Jan 13;403(6766):216-20
All:	45 reference(s)