Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Arnt2tm1Mcs
Name:	aryl hydrocarbon receptor nuclear translocator 2; targeted mutation 1, M Celeste Simon
MGI ID:	MGI:2180386
Synonyms:	Arnt2-
Gene:	Arnt2  Location: Chr7:83895486-84059201 bp, - strand  Genetic Position: Chr7, 48.35 cM
Alliance:	Arnt2tm1Mcs page

Germline Transmission:	Earliest citation of germline transmission: J:69874
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A PGK-neo cassette replaced a portion of the exon encoding the helix-loop-helix domain downstream of the splice acceptor site and the first 91 nucleotides. Western blot analysis of total RNA isolated from cortical neurons showed an absence of protein expression in homozygous mutant embryos. (J:69874)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Arnt2 Mutation:	37 strains or lines available

Original:	J:69874 Keith B, et al., Targeted mutation of the murine arylhydrocarbon receptor nuclear translocator 2 (Arnt2) gene reveals partial redundancy with Arnt. Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6692-7
All:	1 reference(s)