Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Grap2tm1Amch
Name:	GRB2-related adaptor protein 2; targeted mutation 1, Alec M Cheng
MGI ID:	MGI:2180009
Synonyms:	GADS-
Gene:	Grap2  Location: Chr15:80456798-80537055 bp, + strand  Genetic Position: Chr15, 37.88 cM, cytoband E2
Alliance:	Grap2tm1Amch page

Germline Transmission:	Earliest citation of germline transmission: J:76696
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Four exons encoding the C-terminal portion of the SH2 domain, the linker region, and the C-terminal SH3 domain were replaced with a neomycin cassette via homologous recombination. Protein product is absent in spleen from homozygous mutant animals as determined by Western blot analysis. (J:76696)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Grap2 Mutation:	23 strains or lines available

Original:	J:76696 Yoder J, et al., Requirement for the SLP-76 adaptor GADS in T cell development. Science. 2001 Mar 9;291(5510):1987-91
All:	8 reference(s)