Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Relbtm1Brv
Name:	avian reticuloendotheliosis viral (v-rel) oncogene related B; targeted mutation 1, Rodrigo Bravo
MGI ID:	MGI:2179545
Synonyms:	Relb-, RelBKO
Gene:	Relb  Location: Chr7:19340142-19363352 bp, - strand  Genetic Position: Chr7, 9.93 cM
Alliance:	Relbtm1Brv page

Germline Transmission:	Earliest citation of germline transmission: J:22675
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance gene replaced a 0.5 kb fragment containing most of exon 4, which encodes the beginning of the Rel homology domain. Western blot analysis on lysates derived from homozygous mice confirmed that no detectable protein was present. (J:22675)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

25 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Relb Mutation:	32 strains or lines available

Original:	J:22675 Weih F, et al., Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa B/Rel family. Cell. 1995 Jan 27;80(2):331-40
All:	44 reference(s)