Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gabbr1tm1Bet
Name:	gamma-aminobutyric acid type B receptor subunit 1; targeted mutation 1, Bernhard Bettler
MGI ID:	MGI:2159352
Synonyms:	GABAB(1)-, GB1-
Gene:	Gabbr1  Location: Chr17:37356888-37385197 bp, + strand  Genetic Position: Chr17, 19.16 cM
Alliance:	Gabbr1tm1Bet page

Germline Transmission:	Earliest citation of germline transmission: J:70558
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	BALB/c

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin selection cassette replaced a genomic fragment containing exons 7-10. In situ hybridization experiments on brain sections of homozygous mice confirmed that no detectable transcript was produced from this allele. Western blot and radiolabeled binding assays confirmed that no functional protein was expressed in brain of homozygous mice. (J:70558)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gabbr1 Mutation:	71 strains or lines available

Original:	J:70558 Schuler V, et al., Epilepsy, hyperalgesia, impaired memory, and loss of pre- and postsynaptic GABA(B) responses in mice lacking GABA(B(1)). Neuron. 2001 Jul 19;31(1):47-58
All:	28 reference(s)