Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Il18r1tm1Aki
Name:	interleukin 18 receptor 1; targeted mutation 1, Shizuo Akira
MGI ID:	MGI:2136765
Synonyms:	Il18r1-, Il18ralpha-, Il1rrptm1Aki
Gene:	Il18r1  Location: Chr1:40504712-40540014 bp, + strand  Genetic Position: Chr1, 19.27 cM, cytoband B
Alliance:	Il18r1tm1Aki page

Germline Transmission:	Earliest citation of germline transmission: J:70298
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Replacement of the exon encoding amino acids 296-350, encoding the transmembrane region, with a neomycin cassette. No mRNA was detected in liver from homozygous mutant animals, as assayed by RT-PCR. (J:70298)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Il18r1 Mutation:	43 strains or lines available

Original:	J:70298 Hoshino K, et al., Cutting edge: generation of IL-18 receptor-deficient mice: evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor. J Immunol. 1999 May 1;162(9):5041-4
All:	99 reference(s)