Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Vil1tm1Syr
Name:	villin 1; targeted mutation 1, Sylvie Robine
MGI ID:	MGI:1859841
Synonyms:	villin-null
Gene:	Vil1  Location: Chr1:74448543-74474719 bp, + strand  Genetic Position: Chr1, 38.54 cM, cytoband C5
Alliance:	Vil1tm1Syr page

Germline Transmission:	Earliest citation of germline transmission: J:57346
Parent Cell Line:	CK35 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: The open reading frame was disrupted by the insertion of a neomycin selection cassette into exon 2. Normal protein was shown to be absent and no aberrant transcripts were detected via Northern blot and RT-PCR analysis of homozygous mutant mice. Western blot analysis confirmed the absence of encoded protein extracts from intestinal and renal tissue of homozygous mutant mice. (J:57346)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Vil1 Mutation:	50 strains or lines available

Original:	J:57346 Ferrary E, et al., In vivo, villin is required for Ca(2+)-dependent F-actin disruption in intestinal brush borders. J Cell Biol. 1999 Aug 23;146(4):819-30
All:	10 reference(s)