Grm1tm1Stl
Targeted Allele Detail
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Symbol: |
Grm1tm1Stl |
Name: |
glutamate receptor, metabotropic 1; targeted mutation 1, Susumu Tonegawa |
MGI ID: |
MGI:1857987 |
Synonyms: |
mGluR1- |
Gene: |
Grm1 Location: Chr10:10561803-10958100 bp, - strand Genetic Position: Chr10, 3.44 cM, cytoband A2
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Alliance: |
Grm1tm1Stl page
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Germline Transmission: |
Earliest citation of germline transmission:
J:21086
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Parent Cell Line: |
D3 (ES Cell)
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Strain of Origin: |
129S2/SvPas
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A neomycin resistance cassette replaced 2.1kb of the gene, including the 3' portion of exon 1 that encodes amino acids 1 - 233 of the protein. Northern blots of total RNA from cerebella of homozygous mutant mice showed no detectable transcripts of the targeted gene. Western blots of extracts of the cerebella of homozygous mutant mice showed no detectable protein.
(J:21086)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Grm1 Mutation: |
78 strains or lines available
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Original: |
J:21086 Aiba A, et al., Reduced hippocampal long-term potentiation and context-specific deficit in associative learning in mGluR1 mutant mice. Cell. 1994 Oct 21;79(2):365-75 |
All: |
20 reference(s) |
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