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Ccnd1tm1Wbg
Targeted Allele Detail
Summary
Symbol: Ccnd1tm1Wbg
Name: cyclin D1; targeted mutation 1, Robert A Weinberg
MGI ID: MGI:1857280
Synonyms: CD1-, cyclin D1-
Gene: Ccnd1  Location: Chr7:144483668-144493568 bp, - strand  Genetic Position: Chr7, 88.92 cM
Alliance: Ccnd1tm1Wbg page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:28419
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA genomic fragment containing part of exon 1, exon 2 and exon 3 was replaced with a neomycin selection cassette. The deleted sequences encode the cyclin box domain thought to be required for protein activity. Western blot analysis on embryonic fibroblasts derived from homozygous mice confirmed that no stable protein was made from this allele. (J:28419)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 14 assay results
1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 1 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Ccnd1tm1Wbg
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ccnd1 Mutation:  21 strains or lines available
References
Original:  J:28419 Sicinski P, et al., Cyclin D1 provides a link between development and oncogenesis in the retina and breast. Cell. 1995 Aug 25;82(4):621-30
All:  62 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory