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Gene Expression Data
Assay Details
Assay
Reference: J:131297 Froese A, et al., Expression pattern of Popdc2 during mouse embryogenesis and in the adult. Dev Dyn. 2008 Mar;237(3):780-7
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:3776138
Gene symbol: Popdc2
Gene name: popeye domain containing 2
Reporter: lacZ
Direct Detection
Assay notes: Specimens were fixed in 2% formaldehyde, 0.2% glutaraldehyde and post-fixed in 4% paraformaldehyde. For the expression analysis, both homozygous and heterozygous animals were used and no difference in the expression pattern was noted.
Results
Specimen 1A E6.0: embryonic day 6.0; Popdc2tm1Tbd/Popdc2+ (more )
Structure Level Pattern Image Note
TS8: extraembryonic component Present Regionally restricted 1A E6.0 Expression is in the extraembryonic mesoderm.
Specimen 1A E7.0: embryonic day 7.0; Popdc2tm1Tbd/Popdc2+ (more )
Structure Level Pattern Image Note
TS10: extraembryonic mesoderm Strong 1A E7.0
TS10: node Present 1A E7.0
Specimen 1B: embryonic day 7.5; Popdc2tm1Tbd/Popdc2+ (more )
Structure Level Pattern Image Note
TS11: cardiogenic plate Strong Regionally restricted 1B Expression is in the cardiac crescent.
TS11: amnion mesoderm Present 1B
Specimen Not shown: embryonic day 7.5; Popdc2tm1Tbd/Popdc2+ (more )
Structure Level Pattern Image Note
TS11: extraembryonic component Present Regionally restricted Expression is in mesothelial cells covering the allantois.
Specimen 1C: embryonic day 8.5; Popdc2tm1Tbd/Popdc2+ (more )
Structure Level Pattern Image Note
TS13: heart Present 1C
Specimen 1D: embryonic day 10.5; Popdc2tm1Tbd/Popdc2+ (more )
Structure Level Pattern Image Note
TS16: branchial arch Present 1D
TS16: trunk myotome Present 1D
TS16: head mesenchyme Present Regionally restricted 1D Expression is in the putative facial muscle precursor cells.
TS16: trunk Present Regionally restricted 1D Expression is in the ventral and lateral body wall.
Specimen Not shown: embryonic day 10.5; Popdc2tm1Tbd/Popdc2+ (more )
Structure Level Pattern Image Note
TS17: intraembryonic coelom Present Regionally restricted Expression is in the mesothelial layer of the coelomic wall.
TS17: cardiac muscle tissue Present
TS17: endocardial lining Present
TS17: extraembryonic component Present
TS17: heart Present Regionally restricted Expression is in the proepicardium.
Specimen 1E: embryonic day 12.5; Popdc2tm1Tbd/Popdc2+ (more )
Structure Level Pattern Image Note
TS20: intraembryonic coelom Present 1E
TS20: tail dermomyotome Present Regionally restricted 1E Expression is in the myotome.
TS20: limb mesenchyme Present Regionally restricted 1E Expression is in the skeletal muscles of the limb.
TS20: skin Present Regionally restricted 1E Expression is in the ventral body surface.
Specimen 1F: embryonic day 13.5; Popdc2tm1Tbd/Popdc2+ (more )
Structure Level Pattern Image Note
TS21: skeletal muscle Present Regionally restricted 1F Expression is in the muscle anlage in the body.
TS21: heart Present 1F
TS21: limb musculature Present 1F
TS21: midgut Present 1F
TS21: extraembryonic component Present Regionally restricted 1F Expression is in the umbilical cord.
Specimen 1G: embryonic day 7.5; Popdc2tm1Tbd/Popdc2+ (more )
Note: Transversal section through the embryo depicted in (1B).
Structure Level Pattern Image Note
TS11: embryo ectoderm Present 1G
TS11: embryo endoderm Present 1G
TS11: embryo mesoderm Present 1G
TS11: extraembryonic mesoderm Present 1G
TS11: heart Present 1G
Specimen 1H: embryonic day 8.5; Popdc2tm1Tbd/Popdc2+ (more )
Note: Transversal section through the embryo depicted in (1C).
Structure Level Pattern Image Note
TS13: cardiac muscle tissue Present 1H
TS13: dorsal mesocardium Present 1H
TS13: endocardial tube Present 1H
TS13: pericardial component Present 1H
TS13: extraembryonic component Present Regionally restricted 1H Expression is in the amnion.
TS13: foregut diverticulum Present Regionally restricted 1H Expression is in the ventral foregut.
Specimen 1I: embryonic day 10.5; Popdc2tm1Tbd/Popdc2+ (more )
Note: Transversal section through the embryo depicted in (1D).
Structure Level Pattern Image Note
TS17: body wall mesenchyme Present 1I
TS17: dorsal mesocardium Present 1I
TS17: pericardial component Present 1I
TS17: trunk myotome Present 1I
TS17: foregut Present Regionally restricted 1I Expression is in the ventral foregut.
Specimen 1J: embryonic day 12.5; Popdc2tm1Tbd/Popdc2+ (more )
Note: Transversal section through the embryo depicted in (1E).
Structure Level Pattern Image Note
TS20: cardiac muscle tissue Present 1J
TS20: parietal pericardium Present 1J
TS20: endocardial lining Absent 1J
TS20: visceral pericardium Absent 1J
Specimen 1K: embryonic day 13.5; Popdc2tm1Tbd/Popdc2+ (more )
Note: Magnified view of (1J).
Structure Level Pattern Image Note
TS21: cardiac muscle tissue Present 1K
TS21: parietal pericardium Present 1K
TS21: endocardial tissue Absent 1K
TS21: visceral pericardium Absent 1K
Specimen 2A: embryonic day 12.5; Popdc2tm1Tbd/Popdc2+ (more )
Structure Level Pattern Image Note
TS20: heart Present 2A
TS20: tongue muscle Present 2A
TS20: smooth muscle tissue Present Regionally restricted 2A Expression is in the smooth muscle of the gut and bladder.
Specimen 2B: embryonic day 12.5; Popdc2tm1Tbd/Popdc2+ (more )
Note: Magnified view of boxed region in (2A).
Structure Level Pattern Image Note
TS20: tongue muscle Present 2B
Specimen 2C: embryonic day 12.5; Popdc2tm1Tbd/Popdc2+ (more )
Note: Magnified view of boxed region in (2A).
Structure Level Pattern Image Note
TS20: heart Present 2C
Specimen 2D: embryonic day 12.5; Popdc2tm1Tbd/Popdc2+ (more )
Note: Magnified view of boxed region in (2A).
Structure Level Pattern Image Note
TS20: smooth muscle tissue Present Regionally restricted 2D Expression is in the smooth muscle of the gut and bladder.
Specimen 2I: embryonic day 14.5; Popdc2tm1Tbd/Popdc2+ (more )
Structure Level Pattern Image Note
TS22: heart Present 2I
TS22: skeletal muscle Present 2I
Specimen 2K: embryonic day 17.5; Popdc2tm1Tbd/Popdc2+ (more )
Structure Level Pattern Image Note
TS25: heart Present 2K
TS25: pulmonary vein Present 2K
TS25: skeletal muscle Present 2K
Specimen 2M: embryonic day 15.5; Popdc2tm1Tbd/Popdc2+ (more )
Structure Level Pattern Image Note
TS23: skeletal muscle Strong 2M
Specimen 2N: embryonic day 17.5; Popdc2tm1Tbd/Popdc2+ (more )
Structure Level Pattern Image Note
TS25: tongue muscle Present 2N
Specimen 2O: embryonic day 17.5; Popdc2tm1Tbd/Popdc2+ (more )
Structure Level Pattern Image Note
TS25: skeletal muscle Present 2O
TS25: brown fat Absent 2O
TS25: epidermis Absent 2O
Specimen 2P: embryonic day 17.5; Popdc2tm1Tbd/Popdc2+ (more )
Structure Level Pattern Image Note
TS25: skeletal muscle Present 2P Expression is in nuclei of the myofibers.
Specimen 2Q: embryonic day 13.5; Popdc2tm1Tbd/Popdc2+ (more )
Structure Level Pattern Image Note
TS21: primitive bladder Present 2Q
TS21: umbilical artery Present 2Q
TS21: umbilical vein Present 2Q
TS21: midgut loop Present Regionally restricted 2Q Expression is in the mesothelial cells of the dorsal mesentery and mesenchymal cells within the wall of the midgut loop.
TS21: midgut loop dorsal mesentery Present Regionally restricted 2Q Expression is in the mesothelial cells of the dorsal mesentery and mesenchymal cells within the wall of the midgut loop.
TS21: extraembryonic component Present Regionally restricted 2Q Expression is in the umbilical cord.
Specimen 2R: embryonic day 13.5; Popdc2tm1Tbd/Popdc2+ (more )
Structure Level Pattern Image Note
TS21: umbilical artery Present Regionally restricted 2R Expression is in smooth muscle cells.
TS21: umbilical vein Present Regionally restricted 2R Expression is in smooth muscle cells.
Specimen 3A: postnatal month 3; Popdc2tm1Tbd/Popdc2+ (more )
Structure Level Pattern Image Note
TS28: cardiac muscle tissue Strong 3A The conduction tissue revealed a higher expression level than working myocardium.
Specimen 3B: postnatal month 3; Popdc2tm1Tbd/Popdc2+ (more )
Structure Level Pattern Image Note
TS28: cardiac muscle tissue Present 3B
TS28: coronary artery Absent 3B
TS28: endocardial tissue Absent 3B
TS28: heart valve Absent 3B
TS28: visceral serosal pericardium Absent 3B
Specimen 3C: postnatal day 6-7; Popdc2tm1Tbd/Popdc2+ (more )
Structure Level Pattern Image Note
TS28: cardiac muscle tissue Present 3C
TS28: coronary artery Absent 3C
TS28: endocardial tissue Absent 3C
TS28: heart valve Absent 3C
TS28: visceral serosal pericardium Absent 3C
Specimen 3D: postnatal day 6-7; Popdc2tm1Tbd/Popdc2+ (more )
Structure Level Pattern Image Note
TS28: cardiac muscle tissue Strong 3D
TS28: coronary artery Absent 3D
TS28: endocardial tissue Absent 3D
TS28: heart valve Absent 3D
TS28: visceral serosal pericardium Absent 3D
Specimen 3E: postnatal day 6-7; Popdc2tm1Tbd/Popdc2+ (more )
Structure Level Pattern Image Note
TS28: pulmonary vein Present Regionally restricted 3E Expression is in the proximal but not the distal part of the pulmonary veins.
Specimen 3F: postnatal day 6-7; Popdc2tm1Tbd/Popdc2+ (more )
Structure Level Pattern Image Note
TS28: diaphragm Strong Uniform 3F
TS28: heart Strong Uniform 3F
Specimen 3G: postnatal day 6-7; Popdc2tm1Tbd/Popdc2+ (more )
Structure Level Pattern Image Note
TS28: skeletal muscle Strong Uniform 3G
Specimen 3H: postnatal day 6-7; Popdc2tm1Tbd/Popdc2+ (more )
Structure Level Pattern Image Note
TS28: cardiac muscle tissue Strong Uniform 3H
TS28: intercostal muscle Strong Uniform 3H
TS28: pericardium Strong Uniform 3H
Specimen 3I: postnatal day 6-7; Popdc2tm1Tbd/Popdc2+ (more )
Structure Level Pattern Image Note
TS28: upper leg muscle Strong Uniform 3I
Specimen 3J: postnatal day 6-7; Popdc2tm1Tbd/Popdc2+ (more )
Structure Level Pattern Image Note
TS28: esophagus muscularis Strong Regionally restricted 3J Expression is in the muscularis externae of esophagus.
Specimen 3K: postnatal day 6-7; Popdc2tm1Tbd/Popdc2+ (more )
Structure Level Pattern Image Note
TS28: ascending colon Present Regionally restricted 3K Expression is in the smooth muscle layer.
Specimen Not shown: postnatal; Popdc2tm1Tbd/Popdc2+ (more )
Structure Level Pattern Image Note
TS28: alimentary system Present Regionally restricted Expression was observed in smooth muscle tissue of colon, rectum, and bladder and no expression was seen in smooth muscle layers of other parts of the gastrointestinal tract.
TS28: intestine smooth muscle Present Regionally restricted Expression was observed in smooth muscle tissue of colon, rectum, and bladder and no expression was seen in smooth muscle layers of other parts of the gastrointestinal tract.
TS28: rectum Present Regionally restricted Expression was observed in smooth muscle tissue of colon, rectum, and bladder and no expression was seen in smooth muscle layers of other parts of the gastrointestinal tract.
Specimen 3L: postnatal month 3; Popdc2tm1Tbd/Popdc2+ (more )
Structure Level Pattern Image Note
TS28: ascending colon Present Regionally restricted 3L Expression is in the smooth muscle layer.
Specimen 3M: postnatal month 3; Popdc2tm1Tbd/Popdc2+ (more )
Structure Level Pattern Image Note
TS28: detrusor muscle of bladder Present 3M
Specimen 3N: postnatal day 6-7; Popdc2tm1Tbd/Popdc2+ (more )
Structure Level Pattern Image Note
TS28: pyloric antrum Present Regionally restricted 3N Expression is in the epithelium.
TS28: stomach fundus Absent 3N
Specimen 3O: postnatal day 6-7; Popdc2tm1Tbd/Popdc2+ (more )
Structure Level Pattern Image Note
TS28: pyloric antrum Present Regionally restricted 3O Expression is in the epithelium.
TS28: stomach fundus Absent 3O
Specimen 3Q: postnatal day 6-7; Popdc2tm1Tbd/Popdc2+ (more )
Note: Magnified view of boxed region in (3O).
Structure Level Pattern Image Note
TS28: pyloric antrum Present Regionally restricted 3Q Expression is in the epithelium.
TS28: stomach fundus Absent 3Q
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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