Frat1<tm1Brn> Targeted Allele Detail MGI Mouse (MGI:2384128)

Frat1^tm1Brn
Targeted Allele Detail

Summary

Symbol:	Frat1^tm1Brn
Name:	frequently rearranged in advanced T cell lymphomas; targeted mutation 1, Anton Berns
MGI ID:	MGI:2384128
Synonyms:	Frat1^-, Frat1^lacZ
Gene:	Frat1 Location: Chr19:41818409-41821022 bp, + strand Genetic Position: Chr19, 35.3 cM
Alliance:	Frat1^tm1Brn page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:58550
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:		Targeted (Null/knockout, Reporter)
Mutations:		Insertion, Intragenic deletion
		Mutation details: 660 nucleotides of the coding region were replaced with a cassette containing a lacZ beta-galactosidase gene and hygromycin selection gene. Expression of lacZ was driven by the endogenous promoter. Northern blot analysis confirmed the absence of transcript produced from the targeted locus. (J:58550)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:

79 assay results

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Frat1 Mutation:	9 strains or lines available

References

Original:	J:58550 Jonkers J, et al., In vivo analysis of Frat1 deficiency suggests compensatory activity of Frat3. Mech Dev. 1999 Nov;88(2):183-94
All:	3 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/22/2024 MGI 6.24