Results
|
Specimen
4C:
embryonic day 10.5
(more )
Specimen
4C:
(close )
Genetic Background:
|
CD-1
|
Age:
|
embryonic day 10.5
|
Sex:
|
Not Specified
|
Type:
|
whole mount
|
Fixation:
|
4% Paraformaldehyde
|
Structure |
Level |
Pattern |
Image |
Note |
TS17: telencephalon |
Absent |
|
4C
|
No expression in the medial wall of the telencephalon.
|
TS17: diencephalon |
Present |
Regionally restricted |
4C
|
Expression at the dorsal midline of the diencephalon and midbrain.
|
TS17: midbrain |
Present |
Regionally restricted |
4C
|
Expression at the dorsal midline of the diencephalon and midbrain.
|
Specimen
4H:
embryonic day 10.5
(more )
Specimen
4H:
(close )
Genetic Background:
|
CD-1
|
Age:
|
embryonic day 10.5
|
Sex:
|
Not Specified
|
Type:
|
whole mount
|
Fixation:
|
4% Paraformaldehyde
|
Structure |
Level |
Pattern |
Image |
Note |
TS17: brain |
Strong |
Regionally restricted |
4H
|
Sites of strong expression include the dorsal midline of neural tube (does not continue caudal to isthmus), optic cup, and otic vesicle (pigmented epithelium of the retina).
|
TS17: optic cup |
Strong |
Regionally restricted |
4H
|
Sites of strong expression include the dorsal midline of neural tube (does not continue caudal to isthmus), optic cup, and otic vesicle (pigmented epithelium of the retina).
|
TS17: otocyst |
Strong |
Regionally restricted |
4H
|
Sites of strong expression include the dorsal midline of neural tube (does not continue caudal to isthmus), optic cup, and otic vesicle (pigmented epithelium of the retina).
|
Specimen
not shown:
embryonic day 10.5
(more )
Specimen
not shown:
(close )
Genetic Background:
|
CD-1
|
Age:
|
embryonic day 10.5
|
Sex:
|
Not Specified
|
Type:
|
Not Specified
|
Fixation:
|
4% Paraformaldehyde
|
Specimen
4F:
embryonic day 11.5
(more )
Specimen
4F:
(close )
Genetic Background:
|
CD-1
|
Age:
|
embryonic day 11.5
|
Sex:
|
Not Specified
|
Type:
|
whole mount
|
Fixation:
|
4% Paraformaldehyde
|
Structure |
Level |
Pattern |
Image |
Note |
TS19: telencephalon |
Present |
Regionally restricted |
4F
|
The cortical hem (see below) is delineated by the expression of Wnt2b, Wnt3a and Wnt5a.
|
Specimen
not shown:
embryonic day 11.5
(more )
Specimen
not shown:
(close )
Genetic Background:
|
CD-1
|
Age:
|
embryonic day 11.5
|
Sex:
|
Not Specified
|
Type:
|
Not Specified
|
Fixation:
|
4% Paraformaldehyde
|
Structure |
Level |
Pattern |
Image |
Note |
TS19: hindbrain |
Weak |
Regionally restricted |
|
Weak expression next to the hindbrain site of choroid plexus generation.
|
Specimen
1A:
embryonic day 12.5
(more )
Specimen
1A:
(close )
Genetic Background:
|
CD-1
|
Age:
|
embryonic day 12.5
|
Sex:
|
Not Specified
|
Type:
|
whole mount
|
Fixation:
|
4% Paraformaldehyde
|
Structure |
Level |
Pattern |
Image |
Note |
TS20: telencephalon |
Strong |
Regionally restricted |
1A
|
Strong expression in a band along the caudal 2/3rds of the medial wall, adjacent to the lateral ventricle, defines the cortical hem. At rostral levels, band is dorsal to CPe; at caudal levels, band curves ventrally to surround caudal end of CPe.
|
TS20: diencephalon |
Present |
Regionally restricted |
1A
|
Expression marks the dorsal midline and two patches on either side of the midline.
|
Specimen
1B:
embryonic day 12.5
(more )
Specimen
1B:
(close )
Genetic Background:
|
CD-1
|
Age:
|
embryonic day 12.5
|
Sex:
|
Not Specified
|
Type:
|
whole mount
|
Fixation:
|
4% Paraformaldehyde
|
Structure |
Level |
Pattern |
Image |
Note |
TS20: telencephalon |
Strong |
Regionally restricted |
1B
|
Strong expression in a band along the caudal 2/3rds of the medial wall, adjacent to the lateral ventricle, defines the cortical hem. At rostral levels, band is dorsal to CPe; at caudal levels, band curves ventrally to surround caudal end of CPe.
|
Specimen
2A:
embryonic day 12.5
(more )
Specimen
2A:
(close )
Genetic Background:
|
CD-1
|
Age:
|
embryonic day 12.5
|
Sex:
|
Not Specified
|
Type:
|
whole mount
|
Fixation:
|
4% Paraformaldehyde
|
Structure |
Level |
Pattern |
Image |
Note |
TS20: telencephalon |
Strong |
Regionally restricted |
2A
|
Strong expression in a band along the caudal 2/3rds of the medial wall, adjacent to the lateral ventricle, defines the cortical hem. At rostral levels, band is dorsal to CPe; at caudal levels, band curves ventrally to surround caudal end of CPe.
|
Specimen
1D:
embryonic day 12.5
(more )
Specimen
1D:
(close )
Genetic Background:
|
CD-1
|
Age:
|
embryonic day 12.5
|
Sex:
|
Not Specified
|
Type:
|
section
|
Fixation:
|
4% Paraformaldehyde
|
Embedding:
|
Cryosection
|
Structure |
Level |
Pattern |
Image |
Note |
TS20: telencephalon |
Strong |
Regionally restricted |
1D
|
Expression marks the cortical hem; abuts the CPe dorsally.
|
Specimen
1E:
embryonic day 12.5
(more )
Specimen
1E:
(close )
Genetic Background:
|
CD-1
|
Age:
|
embryonic day 12.5
|
Sex:
|
Not Specified
|
Type:
|
section
|
Fixation:
|
4% Paraformaldehyde
|
Embedding:
|
Cryosection
|
Structure |
Level |
Pattern |
Image |
Note |
TS20: telencephalon |
Strong |
Regionally restricted |
1E
|
Expression marks the cortical hem; no expression in the junctional epithelium between the hem and CPe; abuts the CPe dorsally and caudoventrally.
|
Specimen
1F:
embryonic day 12.5
(more )
Specimen
1F:
(close )
Genetic Background:
|
CD-1
|
Age:
|
embryonic day 12.5
|
Sex:
|
Not Specified
|
Type:
|
section
|
Fixation:
|
4% Paraformaldehyde
|
Embedding:
|
Cryosection
|
Structure |
Level |
Pattern |
Image |
Note |
TS20: telencephalon |
Strong |
Regionally restricted |
1F
|
Expression marks the cortical hem; abuts the CPe caudally.
|
Specimen
2C:
embryonic day 12.5
(more )
Specimen
2C:
(close )
Genetic Background:
|
CD-1
|
Age:
|
embryonic day 12.5
|
Sex:
|
Not Specified
|
Type:
|
section
|
Fixation:
|
4% Paraformaldehyde
|
Embedding:
|
Cryosection
|
Structure |
Level |
Pattern |
Image |
Note |
TS20: telencephalon |
Strong |
Regionally restricted |
2C
|
Expression marks the cortical hem; no expression in the junctional epithelium between the hem and CPe; abuts the CPe.
|
Specimen
7I:
embryonic day 12.5
(more )
Specimen
7I:
(close )
Genetic Background:
|
CD-1
|
Age:
|
embryonic day 12.5
|
Sex:
|
Not Specified
|
Type:
|
section
|
Fixation:
|
4% Paraformaldehyde
|
Embedding:
|
Cryosection
|
Structure |
Level |
Pattern |
Image |
Note |
TS20: telencephalon |
Strong |
Regionally restricted |
7I
|
Expression marks the cortical hem; no expression in the junctional epithelium between the hem and CPe; abuts the CPe.
|
Specimen
2E:
embryonic day 12.5
(more )
Specimen
2E:
(close )
Genetic Background:
|
CD-1
|
Age:
|
embryonic day 12.5
|
Sex:
|
Not Specified
|
Type:
|
section
|
Fixation:
|
4% Paraformaldehyde
|
Embedding:
|
Cryosection
|
Structure |
Level |
Pattern |
Image |
Note |
TS20: telencephalon |
Present |
Regionally restricted |
2E
|
Expression at the ventricular side of the hem, but not in cells close to the pial surface.
|
Specimen
2F:
embryonic day 12.5
(more )
Specimen
2F:
(close )
Genetic Background:
|
CD-1
|
Age:
|
embryonic day 12.5
|
Sex:
|
Not Specified
|
Type:
|
section
|
Fixation:
|
4% Paraformaldehyde
|
Embedding:
|
Cryosection
|
Structure |
Level |
Pattern |
Image |
Note |
TS20: telencephalon |
Present |
Regionally restricted |
2F
|
Expression at the ventricular side of the hem, but not in cells close to the pial surface.
|
Specimen
2G:
embryonic day 12.5
(more )
Specimen
2G:
(close )
Genetic Background:
|
CD-1
|
Age:
|
embryonic day 12.5
|
Sex:
|
Not Specified
|
Type:
|
section
|
Fixation:
|
4% Paraformaldehyde
|
Embedding:
|
Cryosection
|
Structure |
Level |
Pattern |
Image |
Note |
TS20: telencephalon |
Present |
Regionally restricted |
2G
|
Expression at the ventricular side of the hem, but not in cells close to the pial surface.
|
Specimen
7A:
(close )
Genetic Background:
|
involves: C3HeB/FeJ
|
Mutant Allele(s):
|
Gli3Xt-J/Gli3Xt-J
|
Age:
|
embryonic day 12.5
|
Sex:
|
Not Specified
|
Type:
|
whole mount
|
Fixation:
|
4% Paraformaldehyde
|
Structure |
Level |
Pattern |
Image |
Note |
TS20: telencephalon |
Absent |
|
7A
|
In brains of non-exencephalic homozygous mutant mice, no expression was detectable in the telencephalon.
|
TS20: diencephalon |
Present |
Regionally restricted |
7A
|
Expression in some mutant mice at the dorsal midline of the diencephalon.
|
TS20: hindbrain |
Present |
Regionally restricted |
7A
|
Expression next to the fourth ventricle where Ttr-expressing choroid plexus formed.
|
Specimen
7G:
(close )
Genetic Background:
|
involves: C3HeB/FeJ
|
Mutant Allele(s):
|
Gli3Xt-J/Gli3Xt-J
|
Age:
|
embryonic day 12.5
|
Sex:
|
Not Specified
|
Type:
|
section
|
Fixation:
|
4% Paraformaldehyde
|
Embedding:
|
Cryosection
|
Structure |
Level |
Pattern |
Image |
Note |
TS20: telencephalon |
Absent |
|
7G
|
In brains of non-exencephalic homozygous mutant mice, no expression detected at the margin of the medial telencephalic wall.
|
Specimen
7H:
(close )
Genetic Background:
|
involves: C3HeB/FeJ
|
Mutant Allele(s):
|
Gli3Xt-J/Gli3Xt-J
|
Age:
|
embryonic day 12.5
|
Sex:
|
Not Specified
|
Type:
|
section
|
Fixation:
|
4% Paraformaldehyde
|
Embedding:
|
Cryosection
|
Structure |
Level |
Pattern |
Image |
Note |
TS20: inner ear |
Strong |
Regionally restricted |
7H
|
Strong expression at the otic vesicle (inner ear).
|
Specimen
not shown:
(close )
Genetic Background:
|
involves: C3HeB/FeJ
|
Mutant Allele(s):
|
Gli3Xt-J/Gli3Xt-J
|
Age:
|
embryonic day 12.5
|
Sex:
|
Not Specified
|
Type:
|
Not Specified
|
Fixation:
|
4% Paraformaldehyde
|
Specimen
5A:
embryonic day 14.5
(more )
Specimen
5A:
(close )
Genetic Background:
|
CD-1
|
Age:
|
embryonic day 14.5
|
Sex:
|
Not Specified
|
Type:
|
section
|
Fixation:
|
4% Paraformaldehyde
|
Embedding:
|
Cryosection
|
Structure |
Level |
Pattern |
Image |
Note |
TS22: telencephalon |
Present |
Regionally restricted |
5A
|
By the age at which a hippocampal anlage is identifiable by morphology, expression marks the shrinking cortical hem, which is clearly separate from regions of neuroepithelium though to generate hippocampal neurons.
|
Specimen
5B:
embryonic day 15.5
(more )
Specimen
5B:
(close )
Genetic Background:
|
CD-1
|
Age:
|
embryonic day 15.5
|
Sex:
|
Not Specified
|
Type:
|
section
|
Fixation:
|
4% Paraformaldehyde
|
Embedding:
|
Cryosection
|
Structure |
Level |
Pattern |
Image |
Note |
TS23: telencephalon |
Present |
Regionally restricted |
5B
|
Overlapping expression of Wnt2b, Wnt3a and Wnt5a marks a thin layer of cells along the ventricular side of the hippocampal fimbria-fornix.
|
Specimen
not shown:
(close )
Genetic Background:
|
involves: C3HeB/FeJ
|
Mutant Allele(s):
|
Gli3Xt-J/Gli3Xt-J
|
Age:
|
embryonic day 16.5
|
Sex:
|
Not Specified
|
Type:
|
Not Specified
|
Fixation:
|
4% Paraformaldehyde
|
Structure |
Level |
Pattern |
Image |
Note |
TS24: telencephalon |
Absent |
|
|
Five non-exencephalic homozygous mutants showed no expression in the medial telencephalon.
|
|