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Leprtm1.1(cre/ERT2)Que
Targeted Allele Detail
Summary
Symbol: Leprtm1.1(cre/ERT2)Que
Name: leptin receptor; targeted mutation 1.1, Jianwen Que
MGI ID: MGI:8259642
Synonyms: LeprIRES-creERT2-P2A-EGFP
Gene: Lepr  Location: Chr4:101574601-101672549 bp, + strand  Genetic Position: Chr4, 46.96 cM
Alliance: Leprtm1.1(cre/ERT2)Que page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:367435
Parent Cell Line:  KV1 (ES Cell)
Strain of Origin:  (C57BL/6J x 129S6/SvEvTac)F1
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase, Reporter)
Inducer:    tamoxifen
Mutation:    Insertion
 
Leprtm1.1(cre/ERT2)Que expression driven by 1 gene
 
Mutation details: An IRES-cre/ERT2-P2A-EGFP cassette followed by an FRT-flanked neo cassette were inserted immediately before the 5' end stop codon. Flp-mediated recombination removed the neo cassette. (J:367435)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Lepr (mouse)
Summary of all recombinase alleles driven by Lepr.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lepr Mutation:  123 strains or lines available
References
Original:  J:367435 Fang Y, et al., RUNX2 promotes fibrosis via an alveolar-to-pathological fibroblast transition. Nature. 2025 Apr;640(8057):221-230
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory