Igs2em6(Nfatc1-cre/ERT2)Cya
Endonuclease-mediated Allele Detail
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| Symbol: |
Igs2em6(Nfatc1-cre/ERT2)Cya |
| Name: |
intergenic site 2; endonuclease-mediated mutation 6, Cyagen Biosciences |
| MGI ID: |
MGI:8235601 |
| Synonyms: |
Igs2em1(pHsp68-Nfatc1-CreERT2) |
| Gene: |
Igs2 Location: Chr11:3195460-3195497 bp Genetic Position: Chr11, Syntenic
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| Alliance: |
Igs2em6(Nfatc1-cre/ERT2)Cya page
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| Allele Type: |
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Endonuclease-mediated (Inducible, Recombinase) |
| Inducer: |
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tamoxifen |
| Mutation: |
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Insertion
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Igs2em6(Nfatc1-cre/ERT2)Cya expression driven by
1 gene
Knock-in expression driven by:
| Organism |
Driver Gene |
Note |
| mouse |
Nfatc1 (MGI:102469) |
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Mutation details: H11-pHsp68-Nfatc1-CreERT2 allele was generated by knocking the Hsp68 minimal promoter-Kozak-CreERT2-WPRE-BGH pA-Mouse Nfatc1 enhancer cassette into the mouse H11 safe harbor locus via genome editing. Without tamoxifen treatment, CreERT2 recombinase primarily resides in the cytoplasm; nuclear translocation and recombination activity of CreERT2 only occur upon tamoxifen stimulation. When crossed with allele containing loxP sites, offspring are expected to undergo Cre-mediated recombination between loxP sites in Nfatc1-positive cells following tamoxifen administration.
(J:326541)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Nfatc1
(mouse)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Igs2 Mutation: |
64 strains or lines available
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Analysis Tools
