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Gene Expression Data
Assay Details
Assay
Reference: J:359864 Chen Y, et al., The Ednrb-Aim2-AKT axis regulates neural crest-derived melanoblast proliferation during early development. Development. 2024 Nov 15;151(22):dev202444
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7861732
Gene symbol: Akt1
Gene name: thymoma viral proto-oncogene 1
Antibody: anti-Phospho-Akt (Ser473) #4060
Detection system: Secondary antibody
Results
Specimen 6E WT P-AKT: embryonic day 11.5 (more )
Note: Double labeled: red - Akt1; green - Pmel (assay MGI:7861728).
Structure Cell Type Level Pattern Image Note
TS19: mesenchyme derived from neural crest melanoblast Present 6E WT , 6E WT P-AKT
Specimen 6E Ednrb-/- P-AKT: embryonic day 11.5; Ednrbtm1Myks/Ednrbtm1Myks (more )
Note: Double labeled: red - Akt1; green - Pmel (assay MGI:7861728).
Structure Cell Type Level Pattern Image Note
TS19: mesenchyme derived from neural crest melanoblast Weak 6E Ednrb-/- P-AKT , 6E Ednrb-/- Expression in melanoblasts reduced compared to wild type.
Specimen 6E Ednrb-/-; Aim2-/- P-AKT: embryonic day 11.5; Aim2em2.1Gpt/Aim2em2.1Gpt, Ednrbtm1Myks/Ednrbtm1Myks (more )
Note: Double labeled: red - Akt1; green - Pmel (assay MGI:7861728).
Structure Level Pattern Image Note
TS19: mesenchyme derived from neural crest Present 6E Ednrb-/-:Aim2-/- , 6E Ednrb-/-:Aim2-/- P-AKT Expression restored in melanoblasts.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory