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Gene Expression Data
Assay Details
Assay
Reference: J:359864 Chen Y, et al., The Ednrb-Aim2-AKT axis regulates neural crest-derived melanoblast proliferation during early development. Development. 2024 Nov 15;151(22):dev202444
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7861731
Gene symbol: Mki67
Gene name: antigen identified by monoclonal antibody Ki 67
Antibody: anti-Ki67 (AB9260)
Detection system: Secondary antibody
Results
Specimen 2A Ednrb-/+ lower KI67: embryonic day 11.5; Ednrbtm1Myks/Ednrb+ (more )
Note: Double labeled: red - Mki67; green - Pmel (assay MGI:7861728).
Structure Cell Type Level Pattern Image Note
TS19: trunk mesenchyme derived from neural crest melanoblast Present 2A -/+ lower Ki67 , 2A -/+ lower merged , 2A Ednrb-/+ lower Expression in melanoblasts co-localized with Pmel expression.
Specimen 2A Ednrb-/- lower KI67: embryonic day 11.5; Ednrbtm1Myks/Ednrbtm1Myks (more )
Note: Double labeled: red - Mki67; green - Pmel (assay MGI:7861728).
Structure Cell Type Level Pattern Image Note
TS19: trunk mesenchyme derived from neural crest melanoblast Weak 2A -/- lower Ki67 , 2A -/- lower merged , 2A Ednrb-/- lower Percentage of proliferating melanoblasts decreased compared to Ednrb-/+ embryos.
Specimen 6C WT KI67: embryonic day 11.5 (more )
Note: Double labeled: red - Mki67; green - Pmel (assay MGI:7861728).
Structure Cell Type Level Pattern Image Note
TS19: mesenchyme derived from neural crest melanoblast Present 6C WT , 6C WT KI67 , 6C WT merge Expression in melanoblasts co-localized with Pmel expression.
Specimen 6C Ednrb-/- KI67: embryonic day 11.5; Ednrbtm1Myks/Ednrbtm1Myks (more )
Note: Double labeled: red - Mki67; green - Pmel (assay MGI:7861728).
Structure Cell Type Level Pattern Image Note
TS19: mesenchyme derived from neural crest melanoblast Weak 6C Ednrb-/- merge , 6C Ednrb-/- MKI67 , 6C Ednrb-/- Number of proliferating melanoblasts decreased compared to wild type embryos.
Specimen 6C Ednrb-/-; Aim2-/- KI67: embryonic day 11.5; Aim2em2.1Gpt/Aim2em2.1Gpt, Ednrbtm1Myks/Ednrbtm1Myks (more )
Note: Double labeled: red - Mki67; green - Pmel (assay MGI:7861728).
Structure Cell Type Level Pattern Image Note
TS19: mesenchyme derived from neural crest melanoblast Present 6C Ednrb-/-:Aim2-/- merge , 6C Ednrb-/-:Aim2-/- MKI67 , 6C Ednrb-/-:Aim2-/- Expression in Pmel-expressing melanoblasts significantly increased compared to Ednrb-/- embryos.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory