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Gene Expression Data
Assay Details
Assay
Reference: J:306379 Mohad V, et al., Inactivation of Lats1 and Lats2 highlights the role of hippo pathway effector YAP in larynx and vocal fold epithelium morphogenesis. Dev Biol. 2021 May;473:33-49
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7861497
Gene symbol: Yap1
Gene name: yes-associated protein 1
Antibody: Anti-phospho-YAP (Ser172) D9W2I #13008
Detection system: Secondary antibody coupled to Cy3
Results
Specimen 2C/D: embryonic day 10.5 (more )
Note: Double labeled: red - Yap1 protein; green - Yap1 protein (assay MGI:7861496).
Structure Level Pattern Image Note
TS17: respiratory tract epithelium Trace Regionally restricted 2D inset , 2C , 2D Weak cytoplasmic expression in columnar epithelial progenitors in laryngopharyngeal region.
Specimen 2G/H: embryonic day 11.5 (more )
Note: Double labeled: red - Yap1 protein; green - Yap1 protein (assay MGI:7861496).
Structure Level Pattern Image Note
TS19: respiratory tract epithelium Trace Regionally restricted 2G , 2H inset , 2H Cytoplasmic expression in single cuboidal layer of epithelial progenitors in vocal fold epithelial lamina..
TS19: respiratory tract Weak Regionally restricted 2G , 2H inset , 2H Weak expression in mesenchyme of vocal fold.
Specimen 2K/L: embryonic day 13.5 (more )
Note: Double labeled: red - Yap1 protein; green - Yap1 protein (assay MGI:7861496).
Structure Level Pattern Image Note
TS21: larynx Strong Regionally restricted 2K , 2L inset , 2L Strong cytoplasmic expression in vocal fold epithelium.
Specimen 2O/P: embryonic day 15.5 (more )
Note: Double labeled: red - Yap1 protein; green - Yap1 protein (assay MGI:7861496).
Structure Level Pattern Image Note
TS23: larynx Strong Regionally restricted 2P , 2O Strong cytoplasmic expression in vocal fold epithelium.
Specimen 2S/T: embryonic day 16.5 (more )
Note: Double labeled: red - Yap1 protein; green - Yap1 protein (assay MGI:7861496).
Structure Level Pattern Image Note
TS24: larynx Strong Regionally restricted 2T , 2S Strong cytoplasmic expression in vocal fold epithelium.
Specimen 2W/X: embryonic day 18.5 (more )
Note: Double labeled: red - Yap1 protein; green - Yap1 protein (assay MGI:7861496).
Structure Cell Type Level Pattern Image Note
TS26: vocal folds epithelial cell Present Regionally restricted 2X , 2W Cytoplasmic expression in epithelial cells.
Specimen 3C/D: postnatal day 0 (more )
Note: Double labeled: red - Yap1 protein; green - Yap1 protein (assay MGI:7861496).
Structure Cell Type Level Pattern Image Note
TS27: vocal folds epithelial cell Present Regionally restricted 3C , 3D Cytoplasmic expression in epithelial cells.
Specimen 3G/H: postnatal day 7 (more )
Note: Double labeled: red - Yap1 protein; green - Yap1 protein (assay MGI:7861496).
Structure Cell Type Level Pattern Image Note
TS28: vocal folds epithelial cell Present Regionally restricted 3H , 3G Cytoplasmic expression in epithelial cells.
Specimen 3K/L: postnatal day 14 (more )
Note: Double labeled: red - Yap1 protein; green - Yap1 protein (assay MGI:7861496).
Structure Cell Type Level Pattern Image Note
TS28: vocal folds epithelial cell Present Regionally restricted 3L , 3K Cytoplasmic expression in epithelial cells.
Specimen 3O/P: postnatal day 28 (more )
Note: Double labeled: red - Yap1 protein; green - Yap1 protein (assay MGI:7861496).
Structure Cell Type Level Pattern Image Note
TS28: vocal folds epithelial cell Present Regionally restricted 3P , 3O Cytoplasmic expression in epithelial cells.
Specimen 3S/T: postnatal day 42 (more )
Note: Double labeled: red - Yap1 protein; green - Yap1 protein (assay MGI:7861496).
Structure Cell Type Level Pattern Image Note
TS28: vocal folds epithelial cell Present Regionally restricted 3S , 3T Cytoplasmic expression in epithelial cells.
Specimen 3W/X: postnatal adult (more )
Note: Double labeled: red - Yap1 protein; green - Yap1 protein (assay MGI:7861496).
Structure Cell Type Level Pattern Image Note
TS28: vocal folds epithelial cell Present Regionally restricted 3X , 3W Expression localized to cytoplasm.
Specimen 6E: postnatal day 0; Lats1tm1.1Jfm/Lats1+, Lats2tm1.1Jfm/Lats2+, Shhtm1(EGFP/cre)Cjt/Shh+ (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS27: vocal folds epithelial cell Absent 6E Expression nearly absent in epitheilal cells.
Specimen 6F: postnatal day 0; Lats1tm1.1Jfm/Lats1tm1.2Jfm, Lats2tm1.1Jfm/Lats2tm1.2Jfm, Shhtm1(EGFP/cre)Cjt/Shh+ (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS27: vocal folds epithelial cell Absent 6F Expression nearly absent in epitheilal cells.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory