Lats1^tm1.2Jfm
Targeted Allele Detail

Summary

• Symbol: Lats1^tm1.2Jfm
• Name: large tumor suppressor; targeted mutation 1.2, James F Martin
• MGI ID: MGI:7861311
• Gene: Lats1 Location: Chr10:7556978-7592224 bp, + strand Genetic Position: Chr10, 2.29 cM, cytoband A1
• Alliance: Lats1^tm1.2Jfm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:306379
• Parent Cell Line: RJ2.2 (ES Cell)
• Strain of Origin: (C57BL/6Brd-Tyr^c-Brd x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A targeting vector was designed to flank exon 4 with loxP sites. This construct also contained a frt-flanked neomycin resistance (neo) cassette. FLP-mediated recombination removed the frt-flanked neo cassette. Cre-mediated recombination removed exon 4. (J:306379)

Expression

In Mice Carrying this Mutation:

9 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lats1 Mutation: 53 strains or lines available

References

• Original: J:306379 Mohad V, et al., Inactivation of Lats1 and Lats2 highlights the role of hippo pathway effector YAP in larynx and vocal fold epithelium morphogenesis. Dev Biol. 2021 May;473:33-49
• All: 1 reference(s)