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Gene Expression Data
Assay Details
Assay
Reference: J:216503 Ka M, et al., MACF1 regulates the migration of pyramidal neurons via microtubule dynamics and GSK-3 signaling. Dev Biol. 2014 Nov 1;395(1):4-18
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7858947
Gene symbol: Pou3f3
Gene name: POU domain, class 3, transcription factor 3
Antibody: anti-Brn1
Detection system: Secondary antibody coupled to Alexa Fluor
Results
Specimen 3A MACF1loxP/+; Nex-cre: postnatal day 10; Macf1tm1Efu/Macf1+, Neurod6tm1(cre)Kan/Neurod6+ (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS28: cerebral cortex cerebral cortex neuron Present Regionally restricted 3A bottom left , 3A top left Immunopositive neurons were relatively accumulated in higher bins (upper layer neurons) of the control cerebral cortex.
Specimen 3A MACF1loxP/loxP; Nex-cre: postnatal day 10; Macf1tm1Efu/Macf1tm1Efu, Neurod6tm1(cre)Kan/Neurod6+ (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS28: cerebral cortex cerebral cortex neuron Present Regionally restricted 3A bottom right , 3A top right The distinct localization pattern of immunopositive neurons was not seen in MACF1<loxP/loxP>;Nex-cre cerebral cortex. Immunopositive neurons in MACF1<loxP/loxP>;Nex-cre mice were found in both higher bins (3, 4) and lower bins (1, 2) of the cortical plate. Immunopositive neurons appeared abnormally spaced in the mutant compared with control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory