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Gene Expression Data
Assay Details
Assay
Reference: J:275567 Zurkirchen L, et al., Yin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner. Nat Commun. 2019 May 16;10(1):2192
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7856689
Gene symbol: Sox2
Gene name: SRY (sex determining region Y)-box 2
Antibody: anti-Sox2 (AB5603)
Detection system: Secondary antibody
Assay notes: Two Sox2 antibodies were described, but the one used in this assay was not detailed. Anti-Sox2 (MAB2018) MGI:5587803 may have been used in this assay.
Results
Specimen S1c E10.5 Sox2: embryonic day 10.5 (more )
Note: Double labeled: red - Sox2; gray - Dcx (assay MGI:7856690).
Structure Cell Type Level Pattern Image Note
TS17: telencephalon neural progenitor cell Present S1c E10.5 Sox2 Dcx , S1c E10.5 Sox2 Dcx inset
Specimen S1c E12.5 Sox2: embryonic day 12.5 (more )
Note: Double labeled: red - Sox2; gray - Dcx (assay MGI:7856690).
Structure Cell Type Level Pattern Image Note
TS20: cerebral cortex neural progenitor cell Present S1c E12.5 Sox2 Dcx inset , S1c E12.5 Sox2 Dcx
Specimen S1c E18.5 Sox2: embryonic day 18.5 (more )
Note: Double labeled: red - Sox2; gray - Dcx (assay MGI:7856690).
Structure Cell Type Level Pattern Image Note
TS26: cerebral cortex neural progenitor cell Present S1c E18.5 Sox2 Dcx , S1c E18.5 Sox2 Dcx inset lower
Specimen S2a Control Sox2: embryonic day 12.5 (more )
Note: The following genotypes were used as controls: Yy1lx/lx, Emx1-Cre Yy1wt/wt, Emx1-Cre Yy1lx/wt. Double labeled: green - Sox2; red - Dcx (assay MGI:7856690).
Structure Cell Type Level Pattern Image Note
TS20: cerebral cortex neural progenitor cell Present S2a Control
Specimen S2a Yy1cKO Sox2: embryonic day 12.5; Emx1tm1(cre)Krj/Emx1+, Yy1tm2.1Yshi/Yy1tm2.1Yshi (more )
Note: Conditional mutant. Double labeled: green - Sox2; red - Dcx (assay MGI:7856690).
Structure Level Pattern Image Note
TS20: cerebral cortex Weak S2a Yy1cKO Number of expressing cells decreased compared to control, but relative abundance of Sox2-expressing to Dcx-expressing cells was not changed.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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