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Gene Expression Data
Assay Details
Assay
Reference: J:235148 Anderson DM, et al., Severe muscle wasting and denervation in mice lacking the RNA-binding protein ZFP106. Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):E4494-503
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7855515
Gene symbol: Chat
Gene name: choline O-acetyltransferase
Antibody: anti-ChAT
Results
Specimen S4A WT: postnatal month 2 (more )
Structure Cell Type Level Pattern Image Note
TS28: spinal cord lumbar region spinal cord motor neuron Present S4A WT Expression is in motor neurons.
Specimen S4A KO: postnatal month 2; Zfp106tm1a(KOMP)Wtsi/Zfp106tm1a(KOMP)Wtsi (more )
Structure Cell Type Level Pattern Image Note
TS28: spinal cord lumbar region spinal cord motor neuron Present S4A KO In this mutant there is a 43% decrease in the number of positive motor neurons compared to wild-type.
Specimen S7B WT top: postnatal month 3 (more )
Note: Double labeled: green - Chat; red - Tardbp (assay MGI:7855533).
Structure Level Pattern Image Note
TS28: spinal cord Present S7B WT ChAt top , S7B WT TDP-43/ChAT Merge
Specimen S7B KO top: postnatal month 3; Zfp106tm1a(KOMP)Wtsi/Zfp106tm1a(KOMP)Wtsi (more )
Note: Double labeled: green - Chat; red - Tardbp (assay MGI:7855533).
Structure Level Pattern Image Note
TS28: spinal cord Present S7B KO TDP-43/ChAT Merge , S7B KO ChAT top
Specimen S7B WT bottom: postnatal month 3 (more )
Note: Double labeled: green - Chat; red - Fus (assay MGI:7855538).
Structure Level Pattern Image Note
TS28: spinal cord Present S7B WT FUS/ChAT Merge , S7B WT ChAt bottom
Specimen S7B KO bottom: postnatal month 3; Zfp106tm1a(KOMP)Wtsi/Zfp106tm1a(KOMP)Wtsi (more )
Note: Double labeled: green - Chat; red - Fus (assay MGI:7855538).
Structure Level Pattern Image Note
TS28: spinal cord Present S7B KO ChAt bottom , S7B KO FUS/ChAT Merge
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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