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Gene Expression Data
Assay Details
Assay
Reference: J:174731 Bielle F, et al., Slit2 activity in the migration of guidepost neurons shapes thalamic projections during development and evolution. Neuron. 2011 Mar 24;69(6):1085-98
Assay type: RNA in situ
MGI Accession ID: MGI:7790980
Gene symbol: Ebf1
Gene name: early B cell factor 1
Probe: Ebf1 probe
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 4B/D: embryonic day 13.5 (more )
Note: Free-floating vibratome section. Artificial overlay: green - Ebf1; purple - Dlx1 (assay MGI:7790981).
Structure Level Pattern Image Note
TS21: lateral ganglionic eminence Present 4B , 4D
TS21: telencephalon Present Regionally restricted 4B , 4D Expressed in the corridor cells, which had a fan shape that converged toward the caudomedial tip of the ventral telencephalon.
Specimen 7A: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: corpus striatum Present 7A
TS21: telencephalon Present Regionally restricted 7A Expressed in the corridor cells, which had a fan shape that converged toward the caudomedial tip of the ventral telencephalon.
Specimen 7B: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: telencephalon Present Regionally restricted 7B Expressed in the corridor cells.
Specimen 7E: embryonic day 13.5; Slit2tm1Matl/Slit2tm1Matl (more )
Structure Level Pattern Image Note
TS21: corpus striatum Present 7E
TS21: telencephalon Present Regionally restricted 7E Expressed in a domain converging toward the midline with ectopic cells near the midline in the mutant. The mutant rostral corridor was wider and less compact.
Specimen 7F: embryonic day 13.5; Slit2tm1Matl/Slit2tm1Matl (more )
Structure Level Pattern Image Note
TS21: telencephalon Present Regionally restricted 7F Positive corridor was distorted toward the rostral midline in the mutant. The mutant rostral corridor was wider and less compact.
TS21: medial ganglionic eminence Present Regionally restricted 7F Ectopic positive cells in the ventricular zone of the ventral region.
Specimen 7I: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: corpus striatum Present 7I
TS21: telencephalon Present Regionally restricted 7I Expressed in the corridor cells.
TS21: thalamus Present Regionally restricted 7I Expressed in dorsal thalamus.
Specimen 7M: embryonic day 13.5; Slit2tm1Matl/Slit2tm1Matl (more )
Structure Level Pattern Image Note
TS21: corpus striatum Present 7M
TS21: thalamus Present Regionally restricted 7M Expressed in dorsal thalamus.
TS21: telencephalon Present Regionally restricted 7M Expression in the caudal corridor was absent in the mutant.
Specimen S4A: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: corpus striatum Present S4A
TS21: telencephalon Present Regionally restricted S4A Expressed in the corridor cells.
Specimen S4D: embryonic day 13.5; Slit2tm1Matl/Slit2tm1Matl (more )
Structure Level Pattern Image Note
TS21: corpus striatum Present S4D
TS21: telencephalon Present Regionally restricted S4D Expressed in a domain converging toward the midline with ectopic cells near the midline in the mutant.
Specimen S4G: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: corpus striatum Present S4G
TS22: telencephalon Present Regionally restricted S4G Expressed in the corridor cells.
Specimen S4J: embryonic day 14.5; Slit1tm1.1Matl/Slit1tm1.1Matl, Slit2tm1Matl/Slit2tm1Matl (more )
Structure Level Pattern Image Note
TS22: corpus striatum Present S4J
TS22: telencephalon Present Regionally restricted S4J Expressed in a domain converging toward the midline with ectopic cells near the midline in the double knockout mutant, similar as in the Slit2-/- mutant.
Specimen S5A: embryonic day 14.0 (more )
Structure Level Pattern Image Note
TS22: corpus striatum Present S5A
TS22: telencephalon Present Regionally restricted S5A Expressed in the corridor cells.
Specimen S5B: embryonic day 14.0 (more )
Structure Level Pattern Image Note
TS22: corpus striatum Present S5B
TS22: telencephalon Present Regionally restricted S5B Expressed in the corridor cells.
Specimen S5C: embryonic day 14.0; Slit1tm1.1Matl/Slit1tm1.1Matl (more )
Structure Level Pattern Image Note
TS22: corpus striatum Present S5C Similar as in the control.
TS22: telencephalon Present Regionally restricted S5C Expressed in the corridor cells, similar as in the control.
Specimen S5D: embryonic day 14.0; Slit1tm1.1Matl/Slit1tm1.1Matl (more )
Structure Level Pattern Image Note
TS22: telencephalon Present Regionally restricted S5D Expressed in the corridor cells, similar as in the control.
TS22: corpus striatum Present S5D Similar as in the control.
Specimen S5E: embryonic day 14.0; Slit1tm1.1Matl/Slit1tm1.1Matl, Slit2tm1Matl/Slit2tm1Matl (more )
Structure Level Pattern Image Note
TS22: corpus striatum Present S5E
TS22: telencephalon Present Regionally restricted S5E Expressed in the corridor cells, which were displaced towards the ventral midline and close to the ventricular surface.
Specimen S5F: embryonic day 14.0; Slit1tm1.1Matl/Slit1tm1.1Matl, Slit2tm1Matl/Slit2tm1Matl (more )
Structure Level Pattern Image Note
TS22: corpus striatum Present S5F
TS22: telencephalon Present Regionally restricted S5F Expressed in the corridor cells, which were displaced towards the ventral midline and close to the ventricular surface.
Specimen S5G: embryonic day 14.0; Slit2tm1Matl/Slit2tm1Matl (more )
Structure Level Pattern Image Note
TS22: corpus striatum Present S5G
TS22: telencephalon Present Regionally restricted S5G Expressed in the corridor cells, which were displaced towards the ventral midline and close to the ventricular surface.
Specimen S5H: embryonic day 14.0; Slit2tm1Matl/Slit2tm1Matl (more )
Structure Level Pattern Image Note
TS22: corpus striatum Present S5H
TS22: telencephalon Present Regionally restricted S5H Expressed in the corridor cells, which were displaced towards the ventral midline and close to the ventricular surface.
Specimen S7A: embryonic day 14.0 (more )
Structure Level Pattern Image Note
TS22: corpus striatum Present S7A
TS22: telencephalon Present Regionally restricted S7A Expressed in the corridor cells.
Specimen S7B: embryonic day 14.0; Robo1tm1Matl/Robo1tm1Matl, Robo2tm1Mrt/Robo2tm1Mrt (more )
Structure Level Pattern Image Note
TS22: corpus striatum Present S7B
TS22: telencephalon Present Regionally restricted S7B Expressed in the corridor cells. The formation of corridor was severely perturbed, with cells displaced towards the ventral midline.
Specimen S7C: embryonic day 14.0; Robo1tm1Matl/Robo1tm1Matl, Robo2tm1Mrt/Robo2tm1Mrt (more )
Structure Level Pattern Image Note
TS22: corpus striatum Present S7C
TS22: telencephalon Present Regionally restricted S7C Expressed in the corridor cells. The formation of corridor was severely perturbed, with cells displaced towards the ventral midline.
Specimen S7D: embryonic day 14.0 (more )
Structure Level Pattern Image Note
TS22: corpus striatum Present S7D
TS22: telencephalon Present Regionally restricted S7D Expressed in the corridor cells.
Specimen S7E: embryonic day 14.0; Robo1tm1Matl/Robo1tm1Matl (more )
Structure Level Pattern Image Note
TS22: corpus striatum Present S7E
TS22: telencephalon Present Regionally restricted S7E Expressed in the corridor cells, similar as in the wild-type.
Specimen S7F: embryonic day 14.0; Robo2tm1Mrt/Robo2tm1Mrt (more )
Structure Level Pattern Image Note
TS22: corpus striatum Present S7F
TS22: telencephalon Present Regionally restricted S7F Expressed in the corridor cells. Limited impact on corridor development was seen, with a more ventral positioning of a patch of positive cells.
Specimen not shown: embryonic day 13.0 (more )
Note: Authors stated that RNA expression was examined on dpc 13-14.5; not all stages are detailed.
Structure Level Pattern Image Note
TS21: corpus striatum Present
TS21: telencephalon Present Regionally restricted Expressed in the corridor cells.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory