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Gene Expression Data
Assay Details
Assay
Reference: J:174095 Cai Z, et al., Loss of shp2-mediated mitogen-activated protein kinase signaling in muller glial cells results in retinal degeneration. Mol Cell Biol. 2011 Jul;31(14):2973-83
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7788478
Gene symbol: Akt1
Gene name: thymoma viral proto-oncogene 1
Antibody: anti-Phospho-Akt (Ser473) #4060
Assay notes: The antibody used recognizes the phosphorylated form of the protein.
Results
Specimen 3D WT: postnatal day 21 (more )
Structure Level Pattern Image Note
TS28: retina layer Present 3D WT
Specimen 3D cKO: postnatal day 21; Ptpn11tm1Gsf/Ptpn11tm1Gsf, Tg(Six3-cre)69Frty/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: retina layer Present 3D cKO Expression intensity or pattern was unchanged.
Specimen 5J: postnatal day 21 (more )
Structure Level Pattern Image Note
TS28: retina layer Present 5J
Specimen 5K: postnatal day 21; Ptpn11tm1Gsf/Ptpn11tm1Gsf, Tg(Six3-cre)69Frty/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: retina layer Present 5K Expression intensity or pattern was unchanged.
Specimen 5L: postnatal day 21; Ptentm1Hwu/Ptentm1Hwu, Tg(Six3-cre)69Frty/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: retina layer Present 5L Increased level of phosphorylation throughout the retina.
Specimen 5M: postnatal day 21; Ptentm1Hwu/Ptentm1Hwu, Ptpn11tm1Gsf/Ptpn11tm1Gsf, Tg(Six3-cre)69Frty/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: retina layer Present 5M Increased level of phosphorylation throughout the retina, with no attenuation of retinal degeneration in the double-knockout mutant.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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