About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:174095 Cai Z, et al., Loss of shp2-mediated mitogen-activated protein kinase signaling in muller glial cells results in retinal degeneration. Mol Cell Biol. 2011 Jul;31(14):2973-83
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7788450
Gene symbol: Pou4f1
Gene name: POU domain, class 4, transcription factor 1
Results
Specimen 2A WT: postnatal day 21 (more )
Structure Cell Type Level Pattern Image Note
TS28: retina ganglion cell layer retinal ganglion cell Present 2A WT
Specimen 2A cKO: postnatal day 21; Ptpn11tm1Gsf/Ptpn11tm1Gsf, Tg(Six3-cre)69Frty/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS28: retina ganglion cell layer retinal ganglion cell Present 2A cKO A 50% reduction was seen.
Specimen S3A: postnatal day 7 (more )
Structure Cell Type Level Pattern Image Note
TS28: retina ganglion cell layer retinal ganglion cell Present S3A
Specimen S3B: postnatal day 7; Ptpn11tm1Gsf/Ptpn11tm1Gsf, Tg(Six3-cre)69Frty/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS28: retina ganglion cell layer retinal ganglion cell Present S3B Similar as in the wild-type.
Specimen not shown: postnatal day 21; Krastm4Tyj/Krastm4Tyj, Ptpn11tm1Gsf/Ptpn11tm1Gsf, Tg(Six3-cre)69Frty/0 (more )
Note: Conditional mutant. Quantified in Fig 6T.
Structure Cell Type Level Pattern Image Note
TS28: retina ganglion cell layer retinal ganglion cell Present Expression was restored to the wild-type level.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory