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Gene Expression Data
Assay Details
Assay
Reference: J:305429 Kaiser M, et al., Regulation of otocyst patterning by Tbx2 and Tbx3 is required for inner ear morphogenesis in the mouse. Development. 2021 Apr 15;148(8):dev195651
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7788413
Gene symbol: Casp3
Gene name: caspase 3
Antibody: anti-cleaved Caspase-3 (Asp175) (#9661)
Detection system: Biotinylated secondary antibody/[Strept]avidin coupled to rhodamine
Results
Specimen S3B E10.5 anterior control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Present Single cells S3B anterior control E10.5 A small cluster of apoptotic cells at the ventral-most tip of the otocyst was present in control.
Specimen S3B E10.5 anterior Tbx2cKO: embryonic day 10.5; Tbx2tm2.1Vmc/Tbx2tm2.1Vmc, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted S3B anterior Tbx2cKO E10.5 Ectopic programmed cell death occurred in the ventro-lateral and dorso-lateral region at this stage.
Specimen S3B E10.5 anterior Tbx3cKO: embryonic day 10.5; Tbx3tm1Pa/Tbx3tm1Pa, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Present Single cells S3B anterior Tbx3cKO E10.5 A small cluster of apoptotic cells at the ventral-most tip of the otocyst was present in Tbx3cKO embryos at E10.5.
Specimen S3B E10.5 anterior Tbx2/3cDKO: embryonic day 10.5; Tbx2tm2.1Vmc/Tbx2tm2.1Vmc, Tbx3tm1Pa/Tbx3tm1Pa, Tg(Pax2-cre)10Shwl/0, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted S3B anterior Tbx2/3cDKO E10.5 Ectopic programmed cell death occurred in the ventro-lateral and dorso-lateral region at this stage.
Specimen S3B E10.5 mid-transverse control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Present Single cells S3B mid-transverse control E10.5 A small cluster of apoptotic cells at the ventral-most tip of the otocyst was present in control.
Specimen S3B E10.5 mid-transverse Tbx2cKO: embryonic day 10.5; Tbx2tm2.1Vmc/Tbx2tm2.1Vmc, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted S3B mid-transverse Tbx2cKO E10.5 Ectopic programmed cell death occurred in the ventro-lateral and dorso-lateral region at this stage.
Specimen S3B E10.5 mid-transverse Tbx3cKO: embryonic day 10.5; Tbx3tm1Pa/Tbx3tm1Pa, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Present Single cells S3B mid-transverse Tbx3cKO E10.5 A small cluster of apoptotic cells at the ventral-most tip of the otocyst was present in Tbx3cKO embryos at E10.5.
Specimen S3B E10.5 mid-transverse Tbx2/3cDKO: embryonic day 10.5; Tbx2tm2.1Vmc/Tbx2tm2.1Vmc, Tbx3tm1Pa/Tbx3tm1Pa, Tg(Pax2-cre)10Shwl/0, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted S3B mid-transverse Tbx2/3cDKO E10.5 Ectopic programmed cell death occurred in the ventro-lateral and dorso-lateral region at this stage.
Specimen S3B E10.5 posterior control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Present Single cells S3B posterior control E10.5 A small cluster of apoptotic cells at the ventral-most tip of the otocyst was present in control.
Specimen S3B E10.5 posterior Tbx2cKO: embryonic day 10.5; Tbx2tm2.1Vmc/Tbx2tm2.1Vmc, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted S3B posterior Tbx2cKO E10.5 Ectopic programmed cell death occurred in the ventro-lateral and dorso-lateral region at this stage.
Specimen S3B E10.5 posterior Tbx3cKO: embryonic day 10.5; Tbx3tm1Pa/Tbx3tm1Pa, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Present Single cells S3B posterior Tbx3cKO E10.5 A small cluster of apoptotic cells at the ventral-most tip of the otocyst was present in Tbx3cKO embryos at E10.5.
Specimen S3B E10.5 posterior Tbx2/3cDKO: embryonic day 10.5; Tbx2tm2.1Vmc/Tbx2tm2.1Vmc, Tbx3tm1Pa/Tbx3tm1Pa, Tg(Pax2-cre)10Shwl/0, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted S3B posterior Tbx2/3cDKO E10.5 Ectopic programmed cell death occurred in the ventro-lateral and dorso-lateral region at this stage.
Specimen S3B E11.5 anterior control: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: otocyst Ambiguous S3B anterior control E11.5
Specimen S3B E11.5 anterior Tbx2cKO: embryonic day 11.5; Tbx2tm2.1Vmc/Tbx2tm2.1Vmc, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: otocyst Present Regionally restricted S3B anterior Tbx2cKO E11.5 Markedly increased apoptosis was detected in the ventral-most area of the otocyst.
Specimen S3B E11.5 anterior Tbx3cKO: embryonic day 11.5; Tbx3tm1Pa/Tbx3tm1Pa, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: otocyst Ambiguous S3B anterior Tbx3cKO E11.5
Specimen S3B E11.5 anterior Tbx2/3cDKO: embryonic day 11.5; Tbx2tm2.1Vmc/Tbx2tm2.1Vmc, Tbx3tm1Pa/Tbx3tm1Pa, Tg(Pax2-cre)10Shwl/0, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: otocyst Present Regionally restricted S3B anterior Tbx2/3cDKO E11.5 Markedly increased apoptosis was detected in the ventral-most area of the otocyst.
Specimen S3B E11.5 mid-transverse control: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: otocyst Ambiguous S3B mid-transverse control E11.5
Specimen S3B E11.5 mid-transverse Tbx2cKO: embryonic day 11.5; Tbx2tm2.1Vmc/Tbx2tm2.1Vmc, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: otocyst Present Regionally restricted S3B mid-transverse Tbx2cKO E11.5 Markedly increased apoptosis was detected in the ventral-most area of the otocyst.
Specimen S3B E11.5 mid-transverse Tbx3cKO: embryonic day 11.5; Tbx3tm1Pa/Tbx3tm1Pa, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: otocyst Ambiguous S3B mid-transverse Tbx3cKO E11.5
Specimen S3B E11.5 mid-transverse Tbx2/3cDKO: embryonic day 11.5; Tbx2tm2.1Vmc/Tbx2tm2.1Vmc, Tbx3tm1Pa/Tbx3tm1Pa, Tg(Pax2-cre)10Shwl/0, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: otocyst Present Regionally restricted S3B mid-transverse Tbx2/3cDKO E11.5 Markedly increased apoptosis was detected in the ventral-most area of the otocyst.
Specimen S3B E11.5 posterior control: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: otocyst Ambiguous S3B posterior control E11.5
Specimen S3B E11.5 posterior Tbx2cKO: embryonic day 11.5; Tbx2tm2.1Vmc/Tbx2tm2.1Vmc, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: otocyst Present Regionally restricted S3B posterior Tbx2cKO E11.5 Markedly increased apoptosis was detected in the ventral-most area of the otocyst.
TS19: inner ear mesenchyme Present Regionally restricted S3B posterior Tbx2cKO E11.5 Expression was detected in cells and ganglion-like structures located in the adjacent periotic mesenchyme.
Specimen S3B E11.5 posterior Tbx3cKO: embryonic day 11.5; Tbx3tm1Pa/Tbx3tm1Pa, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: otocyst Ambiguous S3B posterior Tbx3cKO E11.5
Specimen S3B E11.5 posterior Tbx2/3cDKO: embryonic day 11.5; Tbx2tm2.1Vmc/Tbx2tm2.1Vmc, Tbx3tm1Pa/Tbx3tm1Pa, Tg(Pax2-cre)10Shwl/0, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: otocyst Present Regionally restricted S3B posterior Tbx2/3cDKO E11.5 Markedly increased apoptosis was detected in the ventral-most area of the otocyst.
TS19: inner ear mesenchyme Present Regionally restricted S3B posterior Tbx2/3cDKO E11.5 Expression was detected in cells and ganglion-like structures located in the adjacent periotic mesenchyme.
Specimen S11B anterior control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Ambiguous S11B anterior control
Specimen S11B anterior Tbx1KO: embryonic day 10.5; Tbx1tm1Pa/Tbx1tm1Pa (more )
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted S11B anterior Tbx1KO Apoptosis is increased in the ventral aspect of Tbx1KO otocysts.
Specimen S11B mid-transverse control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Ambiguous S11B mid-transverse control
Specimen S11B mid-transverse Tbx1KO: embryonic day 10.5; Tbx1tm1Pa/Tbx1tm1Pa (more )
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted S11B mid-transverse Tbx1KO Apoptosis is increased in the ventral aspect of Tbx1KO otocysts.
Specimen S11B posterior control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Ambiguous S11B posterior control
Specimen S11B posterior Tbx1KO: embryonic day 10.5; Tbx1tm1Pa/Tbx1tm1Pa (more )
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted S11B posterior Tbx1KO Apoptosis is increased in the ventral aspect of Tbx1KO otocysts.
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/24/2026
MGI 6.24 		The Jackson Laboratory