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Gene Expression Data
Assay Details
Assay
Reference: J:305429 Kaiser M, et al., Regulation of otocyst patterning by Tbx2 and Tbx3 is required for inner ear morphogenesis in the mouse. Development. 2021 Apr 15;148(8):dev195651
Assay type: RNA in situ
MGI Accession ID: MGI:7788241
Gene symbol: Sox3
Gene name: SRY (sex determining region Y)-box 3
Probe: Sox3 probe
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 5D control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Absent 5D control Sox3
TS17: neural tube Present 5D control Sox3
Specimen 5D Tbx2/3cDKO: embryonic day 10.5; Tbx2tm2.1Vmc/Tbx2tm2.1Vmc, Tbx3tm1Pa/Tbx3tm1Pa, Tg(Pax2-cre)10Shwl/0, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted 5D Tbx2/3cDKO Sox3 Ectopic expression was detected in the ventral region of the otocyst in the Tbx2/3cDKO.
TS17: neural tube Present 5D Tbx2/3cDKO Sox3 Expression was detected in the Tbx2/3cDKO, as in control.
Specimen 7A anterior control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Absent 7A anterior control Sox3
Specimen 7A anterior Tbx2/3cDKO: embryonic day 10.5; Tbx2tm2.1Vmc/Tbx2tm2.1Vmc, Tbx3tm1Pa/Tbx3tm1Pa, Tg(Pax2-cre)10Shwl/0, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted 7A anterior Tbx2/3cDKO Sox3 Ectopic expression was detected in Tbx2/3cDKO in the ventral otocyst along the anterior-posterior axis.
Specimen 7A mid-transverse control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Absent 7A mid-transverse control Sox3
Specimen 7A mid-transverse Tbx2/3cDKO: embryonic day 10.5; Tbx2tm2.1Vmc/Tbx2tm2.1Vmc, Tbx3tm1Pa/Tbx3tm1Pa, Tg(Pax2-cre)10Shwl/0, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted 7A mid-transverse Tbx2/3cDKO Sox3 Ectopic expression was detected in Tbx2/3cDKO in the ventral otocyst along the anterior-posterior axis.
Specimen 7A posterior control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Absent 7A posterior control Sox3
Specimen 7A posterior Tbx2/3cDKO: embryonic day 10.5; Tbx2tm2.1Vmc/Tbx2tm2.1Vmc, Tbx3tm1Pa/Tbx3tm1Pa, Tg(Pax2-cre)10Shwl/0, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted 7A posterior Tbx2/3cDKO Sox3 Ectopic expression was detected in Tbx2/3cDKO in the ventral otocyst along the anterior-posterior axis.
Specimen S7A anterior control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Absent S7A anterior control Sox3
Specimen S7A anterior Tbx2cKO: embryonic day 10.5; Tbx2tm2.1Vmc/Tbx2tm2.1Vmc, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted S7A anterior Tbx2cKO Sox3 Ectopic expression was detected in the Tbx2cKO otocyst.
Specimen S7A mid-transverse control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Absent S7A mid-transverse control Sox3
Specimen S7A mid-transverse Tbx2cKO: embryonic day 10.5; Tbx2tm2.1Vmc/Tbx2tm2.1Vmc, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted S7A mid-transverse Tbx2cKO Sox3 Ectopic expression was detected in the Tbx2cKO otocyst.
Specimen S7A posterior control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Absent S7A posterior control Sox3
Specimen S7A posterior Tbx2cKO: embryonic day 10.5; Tbx2tm2.1Vmc/Tbx2tm2.1Vmc, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted S7A posterior Tbx2cKO Sox3 Ectopic expression was detected in the Tbx2cKO otocyst.
Specimen S7B anterior control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Absent S7B anterior control Sox3
Specimen S7B anterior Tbx3cKO: embryonic day 10.5; Tbx3tm1Pa/Tbx3tm1Pa, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Absent S7B anterior Tbx3cKO Sox3 Ectopic expression was not detected in the Tbx3cKO otocyst.
Specimen S7B mid-transverse control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Absent S7B mid-transverse control Sox3
Specimen S7B mid-transverse Tbx3cKO: embryonic day 10.5; Tbx3tm1Pa/Tbx3tm1Pa, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Absent S7B mid-transverse Tbx3cKO Sox3 Ectopic expression was not detected in the Tbx3cKO otocyst.
Specimen S7B posterior control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Absent S7B posterior control Sox3
Specimen S7B posterior Tbx3cKO: embryonic day 10.5; Tbx3tm1Pa/Tbx3tm1Pa, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Absent S7B posterior Tbx3cKO Sox3 Ectopic expression was not detected in the Tbx3cKO otocyst.
Specimen S8 anterior control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Absent S8_anterior control Sox3
Specimen S8 anterior Tbx1KO: embryonic day 10.5; Tbx1tm1Pa/Tbx1tm1Pa (more )
Structure Level Pattern Image Note
TS17: otocyst Absent S8_anterior Tbx1KO Sox3 Ectopic expression was not detected in the Tbx1KO otocyst.
Specimen S8 mid-transverse control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Absent S8_mid-transverse control Sox3
Specimen S8 mid-transverse Tbx1KO: embryonic day 10.5; Tbx1tm1Pa/Tbx1tm1Pa (more )
Structure Level Pattern Image Note
TS17: otocyst Absent S8_mid-transverse Tbx1KO Sox3 Ectopic expression was not detected in the Tbx1KO otocyst.
Specimen S8 posterior control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Absent S8_posterior control Sox3
Specimen S8 posterior Tbx1KO: embryonic day 10.5; Tbx1tm1Pa/Tbx1tm1Pa (more )
Structure Level Pattern Image Note
TS17: otocyst Absent S8_posterior Tbx1KO Sox3 Ectopic expression was not detected in the Tbx1KO otocyst.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory