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Gene Expression Data
Assay Details
Assay
Reference: J:305429 Kaiser M, et al., Regulation of otocyst patterning by Tbx2 and Tbx3 is required for inner ear morphogenesis in the mouse. Development. 2021 Apr 15;148(8):dev195651
Assay type: RNA in situ
MGI Accession ID: MGI:7788183
Gene symbol: Tbx2
Gene name: T-box 2
Probe: Tbx2 probe
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 1A: embryonic day 8.5 (more )
Structure Level Pattern Image Note
TS13: otic placode Present 1A left
Specimen 1B E9.5: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: otocyst epithelium Present Regionally restricted 1B Tbx2 E9.5 At E9.5, Tbx2 was expressed in the epithelium of the entire otocyst with exception of the dorsolateral quadrant.
Specimen 1B E10.5: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted 1B Tbx2 E10.5 Expression was found ventrally in the developing cochlear duct, dorso-medially in the endolymphatic duct and in the central region, the vestibule, but not in the dorso-lateral region.
Specimen 1B E11.5: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: otocyst Present Regionally restricted 1B Tbx2 E11.5 Expression was found ventrally in the developing cochlear duct, dorso-medially in the endolymphatic duct and in the central region, the vestibule, but not in the dorso-lateral region.
Specimen 1B E12.0: embryonic day 12.0 (more )
Structure Level Pattern Image Note
TS20: cochlear duct Present Regionally restricted 1B Tbx2 E12.0 Expression was found ventrally in the cochlear duct.
TS20: inner ear Present Regionally restricted 1B Tbx2 E12.0 Expression was detected dorso-medially in the endolymphatic duct and in the central region, the vestibule, but not in the dorso-lateral region.
TS20: inner ear vestibular component Present 1B Tbx2 E12.0
Specimen S6B anterior control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Present S6B anterior control Tbx2
Specimen S6B anterior Tbx1KO: embryonic day 10.5; Tbx1tm1Pa/Tbx1tm1Pa (more )
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted S6B anterior Tbx1KO Tbx2 In Tbx1-deficient otocysts, expression of Tbx2 expanded into a small anterior-dorsal region but was otherwise unaffected.
Specimen S6B mid-transverse control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Present S6B mid-transverse control Tbx2
Specimen S6B mid-transverse Tbx1KO: embryonic day 10.5; Tbx1tm1Pa/Tbx1tm1Pa (more )
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted S6B mid-transverse Tbx1KO Tbx2 In Tbx1-deficient otocysts, expression of Tbx2 expanded into a small anterior-dorsal region but was otherwise unaffected.
Specimen S6B posterior control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Present S6B posterior control Tbx2
Specimen S6B posterior Tbx1KO: embryonic day 10.5; Tbx1tm1Pa/Tbx1tm1Pa (more )
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted S6B posterior Tbx1KO Tbx2 In Tbx1-deficient otocysts, expression of Tbx2 expanded into a small anterior-dorsal region but was otherwise unaffected.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory