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Gene Expression Data
Assay Details
Assay
Reference: J:173619 Barron F, et al., Downregulation of Dlx5 and Dlx6 expression by Hand2 is essential for initiation of tongue morphogenesis. Development. 2011 Jun;138(11):2249-59
Assay type: RNA in situ
MGI Accession ID: MGI:7782458
Gene symbol: Hand2
Gene name: heart and neural crest derivatives expressed 2
Probe: Hand2 probe
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 5A: embryonic day 10.5; Hand2tm1.1Majh/Hand2tm1.1Majh (more )
Structure Level Pattern Image Note
TS17: 1st branchial arch Present 5A
TS17: 2nd branchial arch Present 5A
Specimen 5B: embryonic day 10.5; H2az2Tg(Wnt1-cre)11Rth/H2az2+, Hand2tm1.1Majh/Hand2tm1.1Majh (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: 1st branchial arch Absent 5B
TS17: 2nd branchial arch Absent 5B
Specimen 6E: embryonic day 10.5; Hand2tm1.1Majh/Hand2tm1.1Majh (more )
Note: ventral view
Structure Level Pattern Image Note
TS17: 1st branchial arch mesenchyme Present Regionally restricted 6E Expressed in the disto-oral region.
TS17: 2nd branchial arch Present 6E
Specimen 6E': embryonic day 10.5; Hand2tm1.1Majh/Hand2tm1.1Majh (more )
Note: oral view
Structure Level Pattern Image Note
TS17: 1st branchial arch mesenchyme Present Regionally restricted 6E' Expressed in the disto-oral region.
Specimen 6F: embryonic day 10.5; H2az2Tg(Wnt1-cre)11Rth/H2az2+, Hand2tm1.1Majh/Hand2tm1.1Majh (more )
Note: Conditional mutant. ventral view
Structure Level Pattern Image Note
TS17: 1st branchial arch Absent 6F
TS17: 2nd branchial arch Absent 6F
Specimen 6F': embryonic day 10.5; H2az2Tg(Wnt1-cre)11Rth/H2az2+, Hand2tm1.1Majh/Hand2tm1.1Majh (more )
Note: Conditional mutant. oral view
Structure Level Pattern Image Note
TS17: 1st branchial arch Absent 6F'
Specimen 6G: embryonic day 11.5; Hand2tm1.1Majh/Hand2tm1.1Majh (more )
Structure Level Pattern Image Note
TS19: lateral lingual swelling Present 6G
Specimen 6H: embryonic day 11.5; H2az2Tg(Wnt1-cre)11Rth/H2az2+, Hand2tm1.1Majh/Hand2tm1.1Majh (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: lateral lingual swelling Absent 6H
Specimen 6I: embryonic day 12.5; Hand2tm1.1Majh/Hand2tm1.1Majh (more )
Structure Level Pattern Image Note
TS20: tongue Present 6I
TS20: mandibular process Present Regionally restricted 6I Expressed in the distal mandibular arch.
Specimen 6J: embryonic day 12.5; H2az2Tg(Wnt1-cre)11Rth/H2az2+, Hand2tm1.1Majh/Hand2tm1.1Majh (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: mandibular process Absent 6J
Specimen not shown: embryonic day 9.5; H2az2Tg(Wnt1-cre)11Rth/H2az2+, Hand2tm1.1Majh/Hand2tm1.1Majh (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: 1st branchial arch Absent
TS15: 2nd branchial arch Absent
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory