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Gene Expression Data
Assay Details
Assay
Reference: J:173619 Barron F, et al., Downregulation of Dlx5 and Dlx6 expression by Hand2 is essential for initiation of tongue morphogenesis. Development. 2011 Jun;138(11):2249-59
Assay type: RNA in situ
MGI Accession ID: MGI:7782457
Gene symbol: Shh
Gene name: sonic hedgehog
Probe: Shh probe
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 3A: embryonic day 12.5; Hand2tm1.1Majh/Hand2tm1.1Majh (more )
Note: upper jaw
Structure Level Pattern Image Note
TS20: vibrissa Present 3A Expressed in the mystacial vibrissae.
TS20: tooth bud Present Regionally restricted 3A Expressed in the incisor fields.
TS20: palatal shelf Present Regionally restricted 3A Expressed in the palatal rugae.
Specimen 3B: embryonic day 12.5; H2az2Tg(Wnt1-cre)11Rth/H2az2+, Hand2tm1.1Majh/Hand2tm1.1Majh (more )
Note: Conditional mutant. upper jaw
Structure Level Pattern Image Note
TS20: vibrissa Present 3B Expressed in the mystacial vibrissae, similar as in the control.
TS20: tooth bud Present Regionally restricted 3B Expressed in the incisor fields, similar as in the control.
TS20: palatal shelf Present Regionally restricted 3B Expressed in the palatal rugae, similar as in the control.
Specimen 3C: embryonic day 12.5; Hand2tm1.1Majh/Hand2tm1.1Majh (more )
Note: lower jaw
Structure Level Pattern Image Note
TS20: tongue epithelium Present Regionally restricted 3C Expressed in the fungiform papilla.
Specimen 3D: embryonic day 12.5; H2az2Tg(Wnt1-cre)11Rth/H2az2+, Hand2tm1.1Majh/Hand2tm1.1Majh (more )
Note: Conditional mutant. lower jaw
Structure Level Pattern Image Note
TS20: lower jaw primordium Present Regionally restricted 3D Expressed in aberrant mystacial vibrissae.
Specimen 3E: embryonic day 12.5; Hand2tm1.1Majh/Hand2tm1.1Majh (more )
Note: lower jaw
Structure Level Pattern Image Note
TS20: tongue epithelium Present Regionally restricted 3E Expressed in the fungiform papilla.
TS20: tooth bud Present Regionally restricted 3E Expressed in the incisor fields.
Specimen 3F: embryonic day 12.5; H2az2Tg(Wnt1-cre)11Rth/H2az2+, Hand2tm1.1Majh/Hand2tm1.1Majh (more )
Note: Conditional mutant. lower jaw
Structure Level Pattern Image Note
TS20: lower jaw primordium Present Regionally restricted 3F With the tongue absent in the mutant, expression was observed diffusely in the anterior oral cavity. Expressed in aberrant mystacial vibrissae.
TS20: tooth bud Present Regionally restricted 3F Expressed in the incisor fields.
Specimen 3G: embryonic day 13.5; Hand2tm1.1Majh/Hand2tm1.1Majh (more )
Structure Level Pattern Image Note
TS21: fungiform papillae Present 3G
Specimen 3H/H': embryonic day 13.5; H2az2Tg(Wnt1-cre)11Rth/H2az2+, Hand2tm1.1Majh/Hand2tm1.1Majh (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: lower jaw Present Regionally restricted 3H Expressed in horizontal stripes resembling rugae of the upper jaw. The aberrant proximal-distal seam had persisted in the lower jaw and joined two other seams in the anterior oral cavity that resembled the fusion point of the primary and secondary palates in the upper jaw.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory