Tg(AR*121Q)3Als
Transgene Detail
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| Symbol: |
Tg(AR*121Q)3Als |
| Name: |
transgene insertion 3, Albert La Spada |
| MGI ID: |
MGI:7767964 |
| Synonyms: |
BAC fxAR121 |
| Transgene: |
Tg(AR*121Q)3Als Location: unknown
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| Alliance: |
Tg(AR*121Q)3Als page
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| Transgene Type: |
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Transgenic (Conditional ready, Humanized sequence, Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(AR*121Q)3Als expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
AR (367) |
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Mutation details: The transgene was designed by fusing two bacterial artificial chromosomes (BACs) to create an AR BAC construct that includes all eight exons (~180 kbp) of the human androgen receptor gene (AR), ~50 kbp of flanking sequence transcriptionally-upstream of the first AR exon and ~23 kbp of flanking sequence transcriptionally-downstream of the last AR exon. Next, AR exon 1 (which includes the translational start site) was flanked with loxP sites, and a 121 glutamine tract (stabilized with CAA interruptions) was introduced into AR exon 1. No other complete loci exist in the 5' or 3' flanking BAC regions. The founder line 3 identified with 121 polyQ repeats was established.
(J:101977, J:214015)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:214015 Cortes CJ, et al., Muscle expression of mutant androgen receptor accounts for systemic and motor neuron disease phenotypes in spinal and bulbar muscular atrophy. Neuron. 2014 Apr 16;82(2):295-307 |
| All: |
5 reference(s) |
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Analysis Tools
