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Gene Expression Data
Assay Details
Assay
Reference: J:181926 Jo HS, et al., Pten coordinates retinal neurogenesis by regulating Notch signalling. EMBO J. 2012 Feb 15;31(4):817-28
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7764448
Gene symbol: Pten
Gene name: phosphatase and tensin homolog
Antibody: anti-Pten
Detection system: Secondary antibody coupled to Cy3
Assay notes: Two Pten antibodies were described, but the one used in this assay was not detailed. Anti-Pten MGI:7764056 may have been used in this assay.
Results
Specimen 1C Pten Pax6-aCre: embryonic day 14.5; Tg(Pax6-cre,GFP)2Pgr/0 (more )
Note: Double labeled: red - Pten; green - Pax reporter.
Structure Cell Type Level Pattern Image Note
TS22: retina retinal progenitor cell Present 1C Pax6-aCre (upper)
Specimen 1C Pten Pten-cko: embryonic day 14.5; Ptentm2Mak/Ptentm2Mak, Tg(Pax6-cre,GFP)2Pgr/0 (more )
Note: Conditional mutant. Double labeled: red - Pten; green - Pax reporter.
Structure Cell Type Level Pattern Image Note
TS22: retina retinal progenitor cell Absent 1C Pten-cko (upper) Expression eliminated in distal retinal progenitor cells.
Specimen S1 Pten Pax6-aCre: embryonic day 14.5; Tg(Pax6-cre,GFP)2Pgr/0 (more )
Note: Double labeled: red - Pten; green - Pax reporter.
Structure Cell Type Level Pattern Image Note
TS22: retina retinal progenitor cell Present S1_Pax6-aCre Merge , S1_Pax6-aCre Pten
Specimen S1 Pten Pten-cko: embryonic day 14.5; Ptentm2Mak/Ptentm2Mak, Tg(Pax6-cre,GFP)2Pgr/0 (more )
Note: Conditional mutant. Double labeled: red - Pten; green - Pax reporter.
Structure Cell Type Level Pattern Image Note
TS22: retina retinal progenitor cell Absent S1_Pten-cko Pten , S1_Pten-cko Merge Expression eliminated in distal retinal progenitor cells.
Specimen S2A Pax6-aCre Distal: postnatal day 4; Tg(Pax6-cre,GFP)2Pgr/0 (more )
Note: Double labeled: red - Pten; green - Pax reporter.
Structure Cell Type Level Pattern Image Note
TS28: retina retinal progenitor cell Present S2A Pax6-aCre Distal
Specimen S2A Pten-cko Distal: postnatal day 4; Ptentm2Mak/Ptentm2Mak, Tg(Pax6-cre,GFP)2Pgr/0 (more )
Note: Conditional mutant. Double labeled: red - Pten; green - Pax reporter.
Structure Cell Type Level Pattern Image Note
TS28: retina retinal progenitor cell Absent S2A Pten-cko Distal
Specimen S2A Pax6-aCre Proximal: postnatal day 4; Tg(Pax6-cre,GFP)2Pgr/0 (more )
Note: Double labeled: red - Pten; green - Pax reporter.
Structure Cell Type Level Pattern Image Note
TS28: retina retinal progenitor cell Present S2A Pax6-aCre Proximal
Specimen S2A Pten-cko Proximal: postnatal day 4; Ptentm2Mak/Ptentm2Mak, Tg(Pax6-cre,GFP)2Pgr/0 (more )
Note: Conditional mutant. Double labeled: red - Pten; green - Pax reporter.
Structure Cell Type Level Pattern Image Note
TS28: retina retinal progenitor cell Absent S2A Pten-cko Proximal
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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