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Gene Expression Data
Assay Details
Assay
Reference: J:181926 Jo HS, et al., Pten coordinates retinal neurogenesis by regulating Notch signalling. EMBO J. 2012 Feb 15;31(4):817-28
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7764443
Gene symbol: Akt1
Gene name: thymoma viral proto-oncogene 1
Antibody: anti-pAkt (Thr473)
Detection system: Secondary antibody coupled to Cy5
Results
Specimen 5A/B pAkt Pax6-aCre: embryonic day 14.5; Tg(Pax6-cre,GFP)2Pgr/0 (more )
Note: Double labeled: blue - Akt1; red - Hes1 (assay MGI:7764463).
Structure Level Pattern Image Note
TS22: retina Present Regionally restricted 5B Pax6-aCre pAkt , 5A Pax6-aCre , 5B Pax6-aCre Merge Expression mutually exclusive with that of Hes1.
Specimen 5A/B pAkt Pten-cko: embryonic day 14.5; Ptentm2Mak/Ptentm2Mak, Tg(Pax6-cre,GFP)2Pgr/0 (more )
Note: Conditional mutant. Double labeled: blue - Akt1; red - Hes1 (assay MGI:7764463).
Structure Cell Type Level Pattern Image Note
TS22: retina amacrine cell Strong Regionally restricted 5B Pten-cKO Merge , 5B Pten-cKO pAkt , 5A Pten-cKO Authors report significant increase in numbers of early born cells types (RGCs, ACs and HZs).
TS22: retina retina horizontal cell Strong Regionally restricted 5B Pten-cKO Merge , 5B Pten-cKO pAkt , 5A Pten-cKO Authors report significant increase in numbers of early born cells types (RGCs, ACs and HZs).
TS22: retina retinal ganglion cell Strong Regionally restricted 5B Pten-cKO Merge , 5B Pten-cKO pAkt , 5A Pten-cKO Authors report significant increase in numbers of early born cells types (RGCs, ACs and HZs).
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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