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Gene Expression Data
Assay Details
Assay
Reference: J:171630 Bagheri-Fam S, et al., Defective survival of proliferating Sertoli cells and androgen receptor function in a mouse model of the ATR-X syndrome. Hum Mol Genet. 2011 Jun 1;20(11):2213-24
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7751461
Gene symbol: Cyp17a1
Gene name: cytochrome P450, family 17, subfamily a, polypeptide 1
Antibody: anti-Cyp17a1 (C-17; sc-46081)
Detection system: Secondary antibody coupled to Alexa Fluor
Results
Specimen 2C Control: postnatal day 70; Atrxtm1Rjg/Y (more )
Note: Double labeled: red - Cyp17a1; green - Laminin.
Structure Cell Type Level Pattern Image Note
TS28: Leydig cell Leydig cell Present 2C Control A dense network of seminiferous tubules surrounded by interstitial cells was seen.
Specimen 2C cKO: postnatal day 70; Atrxtm1Rjg/Y, Plekha5Tg(AMH-cre)1Flor/0 (more )
Note: Conditional mutant. Double labeled: red - Cyp17a1; green - Laminin.
Structure Cell Type Level Pattern Image Note
TS28: Leydig cell Leydig cell Present 2C cKO Tubules were less densely packed, with the interstitial space increased. Though in sections the number of Leydig cells appeared higher, the total number of Leydig cells was comparable with control mice when accounting for the small testis size of the mutant mice.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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