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Gene Expression Data
Assay Details
Assay
Reference: J:171630 Bagheri-Fam S, et al., Defective survival of proliferating Sertoli cells and androgen receptor function in a mouse model of the ATR-X syndrome. Hum Mol Genet. 2011 Jun 1;20(11):2213-24
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7751460
Gene symbol: Atrx
Gene name: ATRX, chromatin remodeler
Antibody: anti-Atrx (H-300, sc-15408)
Detection system: Secondary antibody coupled to Alexa Fluor
Results
Specimen 1A E14.5: embryonic day 14.5 (more )
Note: Double labeled: green - Atrx; red - Amh (assay MGI:7751458).
Structure Cell Type Level Pattern Image Note
TS22: testis Present Widespread 1A E14.5 Expressed in all testicular cell types, with strongest expression in the Sertoli cells.
TS22: Sertoli cell Sertoli cell Strong 1A E14.5 strongest expression
TS22: germ cell of testis Present 1A E14.5
TS22: interstitium of the testis Present 1A E14.5

Specimen 1A E17.5: embryonic day 17.5 (more )
Note: Double labeled: green - Atrx; red - Amh (assay MGI:7751458).
Structure Cell Type Level Pattern Image Note
TS25: germ cell of testis Present 1A E17.5 Expression was less apparent.
TS25: Sertoli cell Sertoli cell Strong 1A E17.5 Remained robustly expressed.

Specimen 1A P28: postnatal day 28 (more )
Structure Cell Type Level Pattern Image Note
TS28: Sertoli cell Sertoli cell Strong 1A P28 Remained robustly expressed.
TS28: germ cell of testis Present 1A P28 Expression was less apparent.

Specimen 1A P70: postnatal day 70 (more )
Structure Cell Type Level Pattern Image Note
TS28: Sertoli cell Sertoli cell Strong 1A P70 Remained robustly expressed.
TS28: germ cell of testis Present 1A P70 Expression was less apparent.

Specimen 1Bii: embryonic day 14.5; Atrxtm1Rjg/Y, Plekha5Tg(AMH-cre)1Flor/0 (more )
Note: Conditional mutant. Double labeled: green - Atrx; red - Amh (assay MGI:7751458).
Structure Cell Type Level Pattern Image Note
TS22: germ cell of testis Present 1Bii
TS22: interstitium of the testis Present 1Bii
TS22: Sertoli cell Sertoli cell Trace 1Bii No expression in about 95% of the Sertoli cells.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory