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Gene Expression Data
Assay Details
Assay
Reference: J:86692 Stenman JM, et al., Tlx controls proliferation and patterning of lateral telencephalic progenitor domains. J Neurosci. 2003 Nov 19;23(33):10568-76
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7738285
Gene symbol: Pax6
Gene name: paired box 6
Antibody: anti-PAX6
Detection system: Biotinylated secondary antibody/[Strept]avidin coupled to horseradish peroxidase
Assay notes: Two Pax6 antibodies were described, but the one used in this assay was not detailed. Anti-PAX6 MGI:7738234 may have been used in this assay.
Results
Specimen 6D: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: lateral ganglionic eminence Strong Regionally restricted 6D High expression wrapping around pallio-LGE angle; stopping in dorsalmost portion of LGE. In addition, expression in stream of cells emanating from ventralmost region of ventricular zone expression domain down to mantle zone.
TS20: lateral ganglionic eminence mantle zone Present 6D
TS20: lateral ganglionic eminence ventricular zone Present 6D
Specimen 6E: embryonic day 12.5; Gsx2tm1Ssp/Gsx2tm1Ssp (more )
Structure Level Pattern Image Note
TS20: lateral ganglionic eminence Present Regionally restricted 6E Ectopic expression in dorsal half of LGE. Number of expressing cells in mantle zone is significantly reduced compared to wild type.
TS20: lateral ganglionic eminence mantle zone Present 6E
Specimen 6F: embryonic day 12.5; Gsx2tm1Ssp/Gsx2tm1Ssp, Nr2e1tm1Rtyu/Nr2e1tm1Rtyu (more )
Structure Level Pattern Image Note
TS20: lateral ganglionic eminence Present Regionally restricted 6F Ectopic expression in dorsal half of LGE. Expression in considerable number of cells in mantle zone.
TS20: lateral ganglionic eminence mantle zone Present 6F
Specimen 6J: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: telencephalon Present Regionally restricted 6J Expression in LGE-pallium angle.
Specimen 6K: embryonic day 14.5; Gsx2tm1Ssp/Gsx2tm1Ssp (more )
Structure Level Pattern Image Note
TS22: lateral ganglionic eminence Present Regionally restricted 6K Ectopic expression in dorsal LGE.
Specimen 6L: embryonic day 14.5; Gsx2tm1Ssp/Gsx2tm1Ssp, Nr2e1tm1Rtyu/Nr2e1tm1Rtyu (more )
Structure Level Pattern Image Note
TS22: telencephalon Present Regionally restricted 6L Expression has retracted to LGE-pallium angle.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory