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Gene Expression Data
Assay Details
Assay
Reference: J:353283 Yermalovich AV, et al., An essential role for Cmtr2 in mammalian embryonic development. Dev Biol. 2024 Jul 31;516:47-58
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7733357
Gene symbol: Cdh5
Gene name: cadherin 5
Antibody: anti-VE-cadherin (AF1002)
Detection system: Secondary antibody coupled to Alexa Fluor 647
Results
Specimen 2B Remodeled WT: embryonic day 9.5 (more )
Structure Cell Type Level Pattern Image Note
TS15: yolk sac endothelial cell Present 2B Remodeled plexus Merged , 2B Remodeled plexus VE-Cadherin
TS15: yolk sac blood vessel endothelial cell Present 2B Remodeled plexus Merged , 2B Remodeled plexus VE-Cadherin
Specimen 2B Full plexus: embryonic day 9.5; Cmtr2tm1.1(KOMP)Vlcg/Cmtr2tm1.1(KOMP)Vlcg (more )
Structure Cell Type Level Pattern Image Note
TS15: yolk sac endothelial cell Present 2B Full plexus VE-Cadherin , 2B Full plexus Merged Staining revealed absence of large, medium, and small vessels formation compared to wild-type littermate controls.
Specimen 2B Partial plexus: embryonic day 9.5; Cmtr2tm1.1(KOMP)Vlcg/Cmtr2tm1.1(KOMP)Vlcg (more )
Structure Cell Type Level Pattern Image Note
TS15: yolk sac endothelial cell Present 2B Partial plexus Merged , 2B Partial plexus VE-Cadherin Staining revealed absence of large, medium, and small vessels formation compared to wild-type littermate controls.
Specimen 3B Control: embryonic day 10.5; Cmtr2em1Smoc/Cmtr2+ (more )
Structure Cell Type Level Pattern Image Note
TS17: yolk sac endothelial cell Present 3B VE-Cadherin Control , 3B Merged Control
TS17: yolk sac blood vessel endothelial cell Present 3B VE-Cadherin Control , 3B Merged Control
Specimen 3B Remodeled plexus: embryonic day 10.5; Cmtr2em1Smoc/Cmtr2em1Smoc, Tg(Tek-cre)12Flv/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS17: yolk sac endothelial cell Present 3B Remodeled plexus Merged , 3B Remodeled plexus VE-Cadherin Staining indicates that this mutant has impairments in vascular remodeling compared to littermate controls.
Specimen 3B Partly Remodeled: embryonic day 10.5; Cmtr2em1Smoc/Cmtr2em1Smoc, Tg(Tek-cre)12Flv/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS17: yolk sac endothelial cell Present 3B Partly remodeled Merged , 3B Partly remodeled VE-Cadherin Staining indicates that this mutant has impairments in vascular remodeling compared to littermate controls.
Specimen 3B Full plexus: embryonic day 10.5; Cmtr2em1Smoc/Cmtr2em1Smoc, Tg(Tek-cre)12Flv/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS17: yolk sac endothelial cell Present 3B Full plexus Merged , 3B Full plexus VE-Cadherin Staining indicates that this mutant has impairments in vascular remodeling compared to littermate controls.
Specimen S2A +/+: embryonic day 10.5 (more )
Structure Cell Type Level Pattern Image Note
TS17: yolk sac endothelial cell Present S2A Remodeled plexus VE-Cadherin , S2A Remodeled plexus Merged
Specimen S2A -/-: embryonic day 10.5; Cmtr2tm1.1(KOMP)Vlcg/Cmtr2tm1.1(KOMP)Vlcg (more )
Structure Cell Type Level Pattern Image Note
TS17: yolk sac endothelial cell Present S2A Full plexus Merged , S2A Full plexus VE-Cadherin Staining revealed absence of large, medium, and small vessels formation compared to wild-type littermate controls.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory