About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:333283 Guan N, et al., Disruption of mitochondrial complex III in cap mesenchyme but not in ureteric progenitors results in defective nephrogenesis associated with amino acid deficiency. Kidney Int. 2022 Jul;102(1):108-120
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7718729
Gene symbol: Six2
Gene name: sine oculis-related homeobox 2
Results
Specimen 5b Cre-: embryonic day 15.5; Uqcrqtm1.1Ncdl/Uqcrqtm1.1Ncdl (more )
Note: Double labeled: green - Six2; red - BrdU.
Structure Level Pattern Image Note
TS23: cap mesenchyme Present 5b SIX2 lower left , 5b SIX2 upper left
Specimen 5b Six2-Qpc-/-: embryonic day 15.5; Tg(Six2-EGFP/cre)1Amc/0, Uqcrqtm1.1Ncdl/Uqcrq+ (more )
Note: Conditional mutant. Double labeled: green - Six2; red - BrdU.
Structure Level Pattern Image Note
TS23: cap mesenchyme Present 5b SIX2 lower right , 5b SIX2 upper right Significant reduction in BrdU-labeled Six2+ cells, compared with the control.
Specimen S6b Cre-: postnatal day 0; Uqcrqtm1.1Ncdl/Uqcrqtm1.1Ncdl (more )
Note: Double labeled: green - Six2; red - 8OHdG.
Structure Level Pattern Image Note
TS27: cap mesenchyme Present S6B left lower , S6B left upper
Specimen S6b Six2-Qpc-/-: postnatal day 0; Tg(Six2-EGFP/cre)1Amc/0, Uqcrqtm1.1Ncdl/Uqcrq+ (more )
Note: Conditional mutant. Double labeled: green - Six2; red - 8OHdG.
Structure Level Pattern Image Note
TS27: cap mesenchyme Present S6B right lower , S6B right upper Reduced number of positive caps compared with the control. No increased staining of 8-hydroxy-2'-deoxyguanosine, an oxidative DNA damage marker, was seen in mutant kidneys.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory