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Gene Expression Data
Assay Details
Assay
Reference: J:166892 Cariboni A, et al., Defective gonadotropin-releasing hormone neuron migration in mice lacking SEMA3A signalling through NRP1 and NRP2: implications for the aetiology of hypogonadotropic hypogonadism. Hum Mol Genet. 2011 Jan 15;20(2):336-44
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7708037
Gene symbol: Gnrh1
Gene name: gonadotropin releasing hormone 1
Antibody: Anti-GnRH/LHRH (20075)
Detection system: Secondary antibody coupled to Alexa Fluor
Results
Specimen 4A: embryonic day 14.5 (more )
Structure Cell Type Level Pattern Image Note
TS22: nose hypothalamic gonadotropin-releasing hormone neuron Present 4A Migrating GnRH neurons were immunolabeled.
Specimen 4C: embryonic day 14.5; Sema3atm1.1Tyag/Sema3atm1.1Tyag (more )
Structure Cell Type Level Pattern Image Note
TS22: head hypothalamic gonadotropin-releasing hormone neuron Present Regionally restricted 4C Immunopositive GnRH neurons were seen to accumulate at the cribriform plate and between the olfactory bulbs, in a location distal to their normal forebrain entry point.
Specimen 4E: embryonic day 14.5 (more )
Structure Cell Type Level Pattern Image Note
TS22: forebrain hypothalamic gonadotropin-releasing hormone neuron Present 4E Migrating GnRH neurons were immunolabeled.
Specimen 4G: embryonic day 14.5; Sema3atm1.1Tyag/Sema3atm1.1Tyag (more )
Structure Cell Type Level Pattern Image Note
TS22: forebrain hypothalamic gonadotropin-releasing hormone neuron Present Single cells 4G Significantly fewer immunopositive neurons were present in the forebrain.
Specimen 6A: embryonic day 14.5 (more )
Structure Cell Type Level Pattern Image Note
TS22: forebrain hypothalamic gonadotropin-releasing hormone neuron Present 6A Many migrating GnRH neurons had reached the forebrain at E14.5.
Specimen 6B: embryonic day 14.5 (more )
Structure Cell Type Level Pattern Image Note
TS22: nose hypothalamic gonadotropin-releasing hormone neuron Present 6B Migrating GnRH neurons were immunolabeled.
TS22: head hypothalamic gonadotropin-releasing hormone neuron Present 6B , 6E Migrating GnRH neurons were immunolabeled in the nasal compartment but not in the area of the cribriform plate between the olfactory bulbs in the wild type.
Specimen 6F: embryonic day 14.5; Nrp1tm1Ddg/Nrp1tm1Ddg, Nrp2tm1Ddg/Nrp2tm1Ddg (more )
Structure Cell Type Level Pattern Image Note
TS22: forebrain hypothalamic gonadotropin-releasing hormone neuron Present Single cells 6F Only a few GnRH neurons had reached the forebrain at E14.5 in the double mutant.
Specimen 6G: embryonic day 14.5; Nrp1tm1Ddg/Nrp1tm1Ddg, Nrp2tm1Ddg/Nrp2tm1Ddg (more )
Structure Cell Type Level Pattern Image Note
TS22: nose hypothalamic gonadotropin-releasing hormone neuron Present 6G Migrating GnRH neurons were immunolabeled.
TS22: head hypothalamic gonadotropin-releasing hormone neuron Present Regionally restricted 6J , 6G Migrating GnRH neurons were immunolabeled in the nasal compartment and in the area of the cribriform plate between the olfactory bulbs.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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01/06/2026
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