About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:154534 Martinez G, et al., Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation. Invest Ophthalmol Vis Sci. 2009 Oct;50(10):4794-806
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7659202
Gene symbol: Cdh1
Gene name: cadherin 1
Antibody: Anti-E-Cadherin (610181; Clone 36)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 4A: embryonic day 13.5 (more )
Note: Fixation was either 10% neutral buffered formalin or 4% paraformaldehyde. Embedding was either in paraffin or OCT (cryosection).
Structure Cell Type Level Pattern Image Note
TS21: lens lens epithelial cell Present 4A
TS21: lens fiber lens fiber cell Ambiguous Regionally restricted 4A Little or no expression was detected in differentiating fiber cells below the equator.
Specimen 4B: embryonic day 13.5; Ctnnb1tm1Mmt/Ctnnb1tm1Mmt, Tg(Cryaa-cre,Tyr)39Mlr/0 (more )
Note: Conditional mutant. Fixation was either 10% neutral buffered formalin or 4% paraformaldehyde. Embedding was either in paraffin or OCT (cryosection).
Structure Cell Type Level Pattern Image Note
TS21: lens lens epithelial cell Present 4B
TS21: lens fiber lens fiber cell Ambiguous Regionally restricted 4B Little or no expression was detected in differentiating fiber cells below the equator.
Specimen 4C: embryonic day 13.5; Ctnnb1tm1Mmt/Ctnnb1tm1Mmt, Tg(Cryaa-cre)10Mlr/0 (more )
Note: Conditional mutant. Fixation was either 10% neutral buffered formalin or 4% paraformaldehyde. Embedding was either in paraffin or OCT (cryosection).
Structure Cell Type Level Pattern Image Note
TS21: lens epithelium lens epithelial cell Present 4C Expression was more intense in epithelial cells of the BetaCat<Ex3>10 lens.
TS21: lens Present Regionally restricted 4C Expression was distinctly detected in cells below the equator.
Specimen 4D: embryonic day 13.5; Apctm1Tno/Apctm1Tno, Tg(Cryaa-cre)10Mlr/0 (more )
Note: Conditional mutant. Fixation was either 10% neutral buffered formalin or 4% paraformaldehyde. Embedding was either in paraffin or OCT (cryosection).
Structure Cell Type Level Pattern Image Note
TS21: lens epithelium lens epithelial cell Present 4D Expression was more intense in epithelial cells of the APC10 lens.
TS21: lens Present Regionally restricted 4D Expression was distinctly detected in cells below the equator.
Specimen not shown: embryonic day 15.5; Ctnnb1tm1Mmt/Ctnnb1tm1Mmt, Tg(Cryaa-cre)10Mlr/0 (more )
Note: Conditional mutant. Fixation was either 10% neutral buffered formalin or 4% paraformaldehyde. Embedding was either in paraffin or OCT (cryosection).
Structure Level Pattern Image Note
TS23: lens fiber Present Regionally restricted BetaCat<Ex3>10 lens at E15.5 displayed similar aggregations of immunopositive, epithelial-like cells in the fiber compartment.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory