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Gene Expression Data
Assay Details
Assay
Reference: J:154534 Martinez G, et al., Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation. Invest Ophthalmol Vis Sci. 2009 Oct;50(10):4794-806
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7659036
Gene symbol: Ctnnb1
Gene name: catenin beta 1
Antibody: anti-beta catenin
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 3C: embryonic day 13.5 (more )
Note: Fixation was either 10% neutral buffered formalin or 4% paraformaldehyde. Embedding was either in paraffin or OCT (cryosection).
Structure Cell Type Level Pattern Image Note
TS21: lens Present Widespread 3C Expression was detectable in all cells.
TS21: lens epithelium lens epithelial cell Strong 3C Expression was particularly strong along epithelial cell membranes.
TS21: lens fiber lens fiber cell Present 3C Expression was detected along cell membranes.
TS21: retina Present Regionally restricted 3C Expression was detected in the optic cup.
Specimen 3D: embryonic day 13.5; Ctnnb1tm1Mmt/Ctnnb1tm1Mmt, Tg(Cryaa-cre,Tyr)39Mlr/0 (more )
Note: Conditional mutant. Fixation was either 10% neutral buffered formalin or 4% paraformaldehyde. Embedding was either in paraffin or OCT (cryosection).
Structure Cell Type Level Pattern Image Note
TS21: lens Very strong Widespread 3D
TS21: lens fiber lens fiber cell Strong Regionally restricted 3D Strong expression was noted in the epithelioid cells in the fiber compartment. The reactivity was localized along membranes, in the cytoplasm and also in nuclei.
Specimen 3E: embryonic day 13.5 (more )
Note: Fixation was either 10% neutral buffered formalin or 4% paraformaldehyde. Embedding was either in paraffin or OCT (cryosection).
Structure Cell Type Level Pattern Image Note
TS21: lens epithelium lens epithelial cell Present 3E Expression was detected along cell membranes.
TS21: lens fiber lens fiber cell Present 3E Expression was detected along cell membranes.
Specimen 3F: embryonic day 13.5; Apctm1Tno/Apctm1Tno, Tg(Cryaa-cre)10Mlr/0 (more )
Note: Conditional mutant. Fixation was either 10% neutral buffered formalin or 4% paraformaldehyde. Embedding was either in paraffin or OCT (cryosection).
Structure Cell Type Level Pattern Image Note
TS21: lens epithelium lens epithelial cell Strong 3F Increased staining was observed compared with wild type, particularly in the cytoplasm of epithelial-like cells.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/24/2026
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