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Gene Expression Data
Assay Details
Assay
Reference: J:250407 Blanco MJ, et al., Developmental expression of membrane type 4-matrix metalloproteinase (Mt4-mmp/Mmp17) in the mouse embryo. PLoS One. 2017;12(9):e0184767
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:7647181
Gene symbol: Mmp17
Gene name: matrix metallopeptidase 17
Reporter: lacZ
Direct Detection
Results
Specimen 1A: embryonic day 8.5; Mmp17tm1Ski/Mmp17+ (more )
Note: 8-somite stage embryo.
Structure Level Pattern Image Note
TS13: endocardial tube Present 1A Expression in endocardial tissue of primitive heart tube.
Specimen 1B: embryonic day 8.5; Mmp17tm1Ski/Mmp17+ (more )
Note: 8-somite stage embryo.
Structure Level Pattern Image Note
TS13: endocardial tube Present 1B Expression in endocardial tissue of primitive heart tube.
Specimen 1C: embryonic day 8.0; Mmp17tm1Ski/Mmp17+ (more )
Note: 6-somite stage embryo.
Structure Cell Type Level Pattern Image Note
TS12: neural fold premigratory neural crest cell Present 1C Expression in neural folds corresponding to premigratory neural crest cells.
Specimen 1D: embryonic day 8.5; Mmp17tm1Ski/Mmp17+ (more )
Note: 10-somite stage embryo.
Structure Cell Type Level Pattern Image Note
TS13: neural crest premigratory neural crest cell Present 1D
TS13: migrating neural crest migratory neural crest cell Present 1D
TS13: somite Present 1D
Specimen 1E: embryonic day 8.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS13: blood vessel Present Regionally restricted 1E Expression in pattern compatible with intersomitic arteries beginning to branch from dorsal aorta.
Specimen 1F: embryonic day 8.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS13: neural tube Present Regionally restricted 1F Expression in neuroepithelial cells.
Specimen 1G: embryonic day 8.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS13: somite Present 1G
Specimen 1H: embryonic day 8.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS13: neural tube floor plate Present 1H
TS13: dorsal aorta Present 1H
Specimen 1I: embryonic day 8.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS13: blood vessel Present Regionally restricted 1I Expression in intersomitic vasculature.
TS13: vascular plexus Present Regionally restricted 1I Expression in perineuronal vascular plexus.
Specimen 1J: embryonic day 8.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS13: blood vessel Present Regionally restricted 1J Expression in intersomitic vasculature.
Specimen 2A: embryonic day 9.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS15: allantois Present 2A
Specimen 2B: embryonic day 9.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS15: intersomitic artery Present 2B Expression in intersomitic arteries sprouting from dorsal aorta.
Specimen 2C: embryonic day 9.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS15: somite Present Regionally restricted 2C Expression in posterior portion of somites.
Specimen 2D: embryonic day 10.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS17: intersomitic artery Present 2D Vascular pattern of expression persists during somite development.
TS17: forelimb bud Present 2D
TS17: hindlimb bud Present 2D
TS17: tail mesenchyme Present Regionally restricted 2D Expression in mesenchymal tail tip.
TS17: chorioallantoic placenta Present Regionally restricted 2D Expression in allantois.
Specimen 2E: embryonic day 10.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS17: dorsal aorta Present 2E
TS17: heart atrium Present 2E
Specimen 2F: embryonic day 11.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS19: intersomitic artery Present 2F Vascular pattern of expression persists during somite development.
TS19: forelimb bud Present 2F
TS19: hindlimb bud Present 2F
Specimen 2G: embryonic day 12.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS20: forelimb Present 2G
TS20: hindlimb Present 2G
TS20: tail mesenchyme Present Regionally restricted 2G Expression in mesenchymal tail tip.
Specimen 2H: embryonic day 12.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS20: forelimb Present 2H
TS20: vibrissa follicle Present 2H
TS20: lens primordium Present 2H
Specimen 2I: embryonic day 14.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS22: forelimb Present 2I
TS22: vibrissa follicle Present 2I
TS22: brain Present 2I
TS22: eyelid Present 2I
TS22: nose Present 2I
TS22: pinna Present 2I
Specimen 3A: embryonic day 8.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS13: endocardial tube Present Regionally restricted 3A Expression in endocardial endothelium of primitive heart tube.
Specimen 3B: embryonic day 14.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS22: visceral pericardium Present Regionally restricted 3B Expression in epicardium of atrium and ventricle.
Specimen 3C: embryonic day 18.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS26: visceral pericardium Present Regionally restricted 3C Expression in epicardium of atrium and ventricle.
Specimen 3D: embryonic day 11.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS19: internal carotid artery Present Regionally restricted 3D Expression in vascular structures branching from internal carotid artery.
Specimen 3E: embryonic day 14.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS22: internal carotid artery Present Regionally restricted 3E Expression in vascular structures branching from internal carotid artery.
Specimen 3F: embryonic day 9.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS15: allantois Present 3F
Specimen 3G: embryonic day 8.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS13: primary head vein Present Regionally restricted 3G Expression in posterior branch.
Specimen 3H: embryonic day 8.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS13: dorsal aorta Present 3H
Specimen 3I: embryonic day 14.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS22: arterial system smooth muscle Present Regionally restricted 3I Expression in dorsal aorta not restricted to endothelium, but also in smooth muscle cells of aortic wall.
TS22: dorsal aorta endothelium Present Regionally restricted 3I Expression in dorsal aorta not restricted to endothelium, but also in smooth muscle cells of aortic wall.
Specimen 5A: embryonic day 10.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS17: forelimb bud Present Regionally restricted 5A Expression in distal regions of forelimb bud.
TS17: forelimb bud mesenchyme Present Regionally restricted 5A Expression in zone of polarizing actiivy.
Specimen 5B: embryonic day 10.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS17: hindlimb bud Present Regionally restricted 5B Expression in proximal regions of hindlimb.
TS17: hindlimb bud mesenchyme Present Regionally restricted 5B Expression in zone of polarizing actiivy.
Specimen 5C: embryonic day 11.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS19: handplate Present Regionally restricted 5C Expression in distal regions of hand plate.
TS19: future arm Present Regionally restricted 5C Expression in developing stylopodial and zeugopodial elements.
Specimen 5D: embryonic day 11.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS19: footplate Present Regionally restricted 5D Expression in distal regions of footplate.
TS19: future leg Present Regionally restricted 5D Expression in developing stylopodial and zeugopodial elements.
Specimen 5E: embryonic day 12.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS20: forearm Present 5E Expression in stylopodium and zeugopodium.
TS20: upper arm Present 5E Expression in stylopodium and zeugopodium.
TS20: hand Present Regionally restricted 5E Expression in proximal regions of handplate.
TS20: forelimb digit Present 5E Expression first observed in digits at E12.5.
Specimen 5F: embryonic day 12.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS20: lower leg Present 5F Expression in stylopodium and zeugopodium.
TS20: upper leg Present 5F Expression in stylopodium and zeugopodium.
TS20: foot Present Regionally restricted 5F Expression in proximal regions of footplate.
TS20: foot mesenchyme Present Regionally restricted 5F Expression in anterior mesenchyme of footplate.
Specimen 5G: embryonic day 14.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS22: forearm Present 5G Expression in stylopodium and zeugopodium.
TS22: upper arm Present 5G Expression in stylopodium and zeugopodium.
TS22: hand Present Regionally restricted 5G Expression in proximal regions of handplate. Expression restricted to metacarpals of digits II, III, IV and V.
Specimen 5H: embryonic day 14.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS22: lower leg Present 5H Expression in stylopodium and zeugopodium.
TS22: upper leg Present 5H Expression in stylopodium and zeugopodium.
TS22: foot Present Regionally restricted 5H Expression restricted to metatarsals of digits II, III, IV and V.
Specimen 5I: embryonic day 14.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS22: forearm Present 5I Expression in stylopodium and zeugopodium.
TS22: upper arm Present 5I Expression in stylopodium and zeugopodium.
TS22: hand Present 5I Expression in proximal regions of handplate. Expression restricted to metacarpals of digits II, III, IV and V.
Specimen 5J: embryonic day 14.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS22: lower leg Present 5J Expression in stylopodium and zeugopodium.
TS22: upper leg Present 5J Expression in stylopodium and zeugopodium.
TS22: foot Present Regionally restricted 5J Expression in stylopodium and zeugopodium.
Specimen 5K: embryonic day 10.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Cell Type Level Pattern Image Note
TS17: hindlimb bud blood vessel endothelial cell Present Regionally restricted 5K Expression in endothelial cells of blood vessels entering limb.
Specimen 5L: embryonic day 10.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Cell Type Level Pattern Image Note
TS17: blood vessel blood vessel endothelial cell Present Regionally restricted 5L Expression in endothelial cells of blood vessels entering limb.
Specimen 5M: embryonic day 10.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS17: forelimb bud Present Regionally restricted 5M Expression in mesenchyme
Specimen 5N: embryonic day 10.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS17: forelimb bud mesenchyme Present 5N
Specimen 5O: embryonic day 14.5; Mmp17tm1Ski/Mmp17+ (more )
Note: Section at distal level.
Structure Level Pattern Image Note
TS22: hand Present 5O
Specimen 5P: embryonic day 14.5; Mmp17tm1Ski/Mmp17+ (more )
Note: Section at distal level.
Structure Level Pattern Image Note
TS22: hand mesenchyme Present Regionally restricted 5P Expression in tendon blastema.
Specimen 5Q: embryonic day 14.5; Mmp17tm1Ski/Mmp17+ (more )
Note: Section at proximal level.
Structure Level Pattern Image Note
TS22: forearm mesenchyme Present Regionally restricted 5Q Expression in subepidermal mesenchymal cells.
Specimen 5R: embryonic day 14.5; Mmp17tm1Ski/Mmp17+ (more )
Note: Section at proximal level.
Structure Level Pattern Image Note
TS22: forelimb muscle Present Regionally restricted 5R Expression in ventral muscle blocks.
Specimen 5S: embryonic day 14.5; Mmp17tm1Ski/Mmp17+ (more )
Note: Section at proximal level.
Structure Level Pattern Image Note
TS22: forearm mesenchyme Present Regionally restricted 5S Expression in subepidermal mesenchymal cells.
Specimen 5T: embryonic day 14.5; Mmp17tm1Ski/Mmp17+ (more )
Note: Section at proximal level.
Structure Level Pattern Image Note
TS22: blood vessel Present Regionally restricted 5T Expression in blood vessels entering muscles.
Specimen 6A: embryonic day 11.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Cell Type Level Pattern Image Note
TS19: neural tube mantle layer motor neuron Present Regionally restricted 6A Expression in ventral column motoneurons.
Specimen 6B: embryonic day 18.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Cell Type Level Pattern Image Note
TS26: spinal cord mantle layer motor neuron Present Regionally restricted 6B Expression in ventral column motoneurons.
Specimen 6C: embryonic day 11.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS19: midbrain floor plate Present 6C
Specimen 6D: embryonic day 14.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS22: main olfactory bulb layer Present Regionally restricted 6D Expression granular cell layer.
Specimen 6E: postnatal day 1; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS27: main olfactory bulb granule cell layer Present 6E
Specimen 6F: postnatal day 1; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS27: corpus striatum Present 6F
TS27: telencephalon septum Present 6F
Specimen 6G: postnatal day 1; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS27: corpus striatum Present 6G
TS27: neocortex Present Regionally restricted 6G Expression in superficial layers of cortex.
Specimen 6H: embryonic day 14.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS22: cerebral cortex Present Regionally restricted 6H Expression in deep layers of cortex.
TS22: dorsal thalamus Present 6H
Specimen 6I: postnatal day 1; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS27: neocortex Present Regionally restricted 6I Expression in superficial layers of cortex.
TS27: hippocampus Present 6I
Specimen 6J: embryonic day 12.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS20: rhombic lip Present 6J
Specimen 6K: embryonic day 14.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS22: cerebellum Present 6K Expression in cerebellum primordium.
Specimen 6L: postnatal day 1; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS27: cerebellum Present Regionally restricted 6L Expression in many cells in cerebellum, possibly corresponding to Purkinje cells.
TS27: cerebellum external granule cell layer Present 6L
Specimen 7A: embryonic day 12.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS20: olfactory epithelium Present Scattered 7A Scattered expression in olfactory epithelium at entrance to nasal cavity.
Specimen 7B: embryonic day 14.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS22: olfactory epithelium Present Scattered 7B Scattered expression in olfactory epithelium at entrance to nasal cavity.
TS22: nasal mesenchyme Present Regionally restricted 7B Expression in surrounding mesenchyme.
TS22: vibrissa dermal component Present Regionally restricted 7B High expression in mesenchymal cells adjacent to primordium of vibrissa follicle.
Specimen 7C: embryonic day 14.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS22: vibrissa dermal component Present Regionally restricted 7C High expression in mesenchymal cells adjacent to primordium of vibrissa follicle.
Specimen 7D: embryonic day 14.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS22: olfactory epithelium Present Scattered 7D Scattered expression in olfactory epithelium at entrance to nasal cavity.
Specimen 7E: embryonic day 14.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS22: upper lip Present Regionally restricted 7E Expression in ventral extremity of upper lip.
TS22: nasal epithelium Present 7E
Specimen 7F: embryonic day 14.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS22: median fibrous septum Present 7F
TS22: tongue intrinsic muscle Present 7F
Specimen 7G: embryonic day 14.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS22: pinna Present 7G
Specimen 7H: embryonic day 16.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS24: pinna Present 7H
Specimen 7I: embryonic day 10.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS17: otocyst Present 7I Expression in otic vesicle.
Specimen 7J: embryonic day 12.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS20: saccule Present Regionally restricted 7J Expression in caudal portion of saccule.
TS20: vestibulo-cochlear ganglion complex Present 7J
Specimen 7K: embryonic day 12.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS20: semicircular canal Present 7K
Specimen 8A: embryonic day 10.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS17: hyaloid cavity Present Regionally restricted 8A Expression in hyaloid artery.
Specimen 8B: embryonic day 11.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS19: hyaloid vascular plexus Present Regionally restricted 8B Expression in hyaloid artery.
Specimen 8C: embryonic day 12.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS20: hyaloid vascular plexus Present Regionally restricted 8C Expression in hyaloid artery.
TS20: lens primordium Present Scattered 8C Scattered expression first detected in lens.
Specimen 8D: embryonic day 14.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS22: lens Present 8D Expression in lens perisist at E14.5
TS22: eyelid Strong 8D Strong expression in in eyelids.
TS22: neural retina Present 8D Some expressing cells in neural retina.
Specimen 8E: postnatal day 1; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS27: retina ganglion cell layer Present 8E
TS27: eyelid Present 8E Expression perisists in eyelids.
Specimen 8F: postnatal day 1; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS27: retina ganglion cell layer Present 8F
Specimen S1A: embryonic day 9.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS15: proepicardium Absent S1A No expression in region of proepicardium.
Specimen S1B: embryonic day 9.5; Mmp17tm1Ski/Mmp17+ (more )
Structure Level Pattern Image Note
TS15: proepicardium Absent S1B No expression in region of proepicardium.
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory