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Gene Expression Data
Assay Details
Assay
Reference: J:299191 Kitazawa M, et al., Deficiency and overexpression of Rtl1 in the mouse cause distinct muscle abnormalities related to Temple and Kagami-Ogata syndromes. Development. 2020 Sep 2;147(21):dev185918
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7643794
Gene symbol: Rtl1
Gene name: retrotransposon Gaglike 1
Antibody: Anti-Rtl1
Detection system: Secondary antibody coupled to Alexa Fluor 555
Results
Specimen 3A Mat-Rtl1 delta: postnatal newborn; Rtl1tm1Fuis/Rtl1tm1Fuis (more )
Note: Deletion upon maternal transmission. Double labeled: red - Rtl1; green - Des (assay MGI:7645156).
Structure Level Pattern Image Note
TS27: forelimb muscle Present Regionally restricted 3A Mat-Rtl1 delta Rtl1 , 3A Mat-Rtl1 delta Merge Expression was detected in the muscle fibers and the sarcolemma as well as around the muscle fiber nuclei in a striped pattern. Expression was localized in the adjoining area of the z-disc close to Desmin.
Specimen 3A WT(m): postnatal newborn (more )
Note: Double labeled: red - Rtl1; green - Des (assay MGI:7645156).
Structure Level Pattern Image Note
TS27: forelimb muscle Present Regionally restricted 3A WT (m) Merge , 3A WT (m) Rtl1 Expression was detected in the muscle fibers and the sarcolemma as well as around the muscle fiber nuclei in a striped pattern. Expression was localized in the adjoining area of the z-disc close to Desmin.
Specimen 3B Mat-Rtl1 delta: postnatal newborn; Rtl1tm1Fuis/Rtl1tm1Fuis (more )
Note: Deletion upon maternal transmission. Double labeled: red - Rtl1; green - Des (assay MGI:7645156).
Structure Level Pattern Image Note
TS27: forelimb muscle Present Regionally restricted 3B Mat-Rtl1 delta Rtl1 , 3B Mat-Rtl1 delta Merge Expression was detected in the adjoining area of the Z-disc; localized on the surface of myofibrils at the Z-disc in an alternated manner with Desmin, but not merged.
Specimen 3B WT(m): postnatal newborn (more )
Note: Double labeled: red - Rtl1; green - Des (assay MGI:7645156).
Structure Level Pattern Image Note
TS27: forelimb muscle Present Regionally restricted 3B WT (m) Merge , 3B WT (m) Rtl1 Expression was detected in the adjoining area of the Z-disc; localized on the surface of myofibrils at the Z-disc in an alternated manner with Desmin, but not merged.
Specimen S8A Mat-Rtl1 delta: postnatal newborn; Rtl1tm1Fuis/Rtl1tm1Fuis (more )
Note: Deletion upon maternal transmission. Double labeled: red - Rtl1; green - Actn2 (assay MGI:7645160).
Structure Level Pattern Image Note
TS27: abdomen musculature Present Regionally restricted S8A Mat-Rtl1 delta Merge , S8A Mat-Rtl1 delta Rtl1 Expression was detected in the muscle fibers and the sarcolemma as well as around the muscle fiber nuclei in a striped pattern. Expression pattern was similar to that of alpha-actinin, but was not merged.
Specimen S8B Mat-Rtl1 delta: postnatal newborn; Rtl1tm1Fuis/Rtl1tm1Fuis (more )
Note: Deletion upon maternal transmission. Double labeled: red - Rtl1; green - Actn2 (assay MGI:7645160).
Structure Level Pattern Image Note
TS27: abdomen musculature Present Regionally restricted S8B Mat-Rtl1 delta Merge , S8B Mat-Rtl1 delta Rtl1 Expression was detected in the muscle fibers and the sarcolemma as well as around the muscle fiber nuclei in a striped pattern. Expression pattern was similar to that of alpha-actinin, but was not merged.
Specimen S8C Pat-Rtl1 delta: postnatal newborn; Rtl1tm1Fuis/Rtl1tm1Fuis (more )
Note: Deletion upon paternal transmission. Double labeled: red - Rtl1; green - Des (assay MGI:7645156).
Structure Level Pattern Image Note
TS27: intercostal muscle Absent S8C Pat-Rtl1 delta Rtl1 , S8C Pat-Rtl1 delta Merge
Specimen S8C WT: postnatal newborn (more )
Note: Double labeled: red - Rtl1; green - Des (assay MGI:7645156).
Structure Level Pattern Image Note
TS27: intercostal muscle Present Regionally restricted S8C WT Rtl1 , S8C WT Merge Expression was detected in the adjoining area of the Z-disc; localized on the surface of myofibrils at the Z-disc in an alternated manner with Desmin, but not merged.
Specimen S8C Mat-Rtl1 delta: postnatal newborn; Rtl1tm1Fuis/Rtl1tm1Fuis (more )
Note: Deletion upon maternal transmission. Double labeled: red - Rtl1; green - Des (assay MGI:7645156).
Structure Level Pattern Image Note
TS27: intercostal muscle Present Regionally restricted S8C Mat-Rtl1 delta Merge , S8C Mat-Rtl1 delta Rtl1 Expression was detected in the adjoining area of the Z-disc; localized on the surface of myofibrils at the Z-disc in an alternated manner with Desmin, but not merged.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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