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Gene Expression Data
Assay Details
Assay
Reference: J:308858 Fu M, et al., 37/67-laminin receptor facilitates neural crest cell migration during enteric nervous system development. FASEB J. 2020 Aug;34(8):10931-10947
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7639814
Gene symbol: Rpsa
Gene name: ribosomal protein SA
Antibody: anti-37/67 kDa Laminin receptor
Detection system: Secondary antibody
Results
Specimen 1B NCC+/+: postnatal day 7-11; Ednrbtm1Nrd/Ednrbtm1Nrd (more )
Note: Colonic myenteric plexus. Double labeled: green - Rpsa; red - Elavl3 (assay MGI:7639768) and Elavl4 (assay MGI:7639947).
Structure Cell Type Level Pattern Image Note
TS28: myenteric nerve plexus enteric neuron Present 1B +/+ 37/67-LAMR , 1B +/+ merge Expressed in the cytoplasm and nuclei.
Specimen 1B NCC-/-: postnatal day 7-11; Ednrbtm1Nrd/Ednrbtm1Nrd, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant. Colonic myenteric plexus. Double labeled: green - Rpsa; red - Elavl3 (assay MGI:7639768) and Elavl4 (assay MGI:7639947).
Structure Cell Type Level Pattern Image Note
TS28: myenteric nerve plexus enteric neuron Weak 1B -/- merge , 1B -/- 37/67-LAMR Decreased expression with altered localization (primarily intracellular), and appeared restricted to the nucleus in the mutants.
Specimen 3A: embryonic day 13.5; Ednrbtm1Nrd/Ednrbtm1Nrd (more )
Note: Colon. Double labeled: green - Rpsa; red - Sox10 (assay MGI:7639816).
Structure Cell Type Level Pattern Image Note
TS21: migrating neural crest migratory enteric neural crest cell Present 3A merge , 3A 37/67-LAMR
Specimen 3B: embryonic day 13.5; Ednrbtm1Nrd/Ednrbtm1Nrd, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant. Colon. Double labeled: green - Rpsa; red - Sox10 (assay MGI:7639816).
Structure Cell Type Level Pattern Image Note
TS21: migrating neural crest migratory enteric neural crest cell Weak 3B merge , 3B 37/67-LAMR Decreased expression compared with the wild-type.
Specimen S2 NCC+/+: postnatal; Ednrbtm1Nrd/Ednrbtm1Nrd (more )
Note: Small intestine myenteric plexus. Double labeled: green - Rpsa; red - Elavl3 (assay MGI:7639768) and Elavl4 (assay MGI:7639947).
Structure Cell Type Level Pattern Image Note
TS28: myenteric nerve plexus enteric neuron Present S2+/+ merge , S2+/+ 37/67-LAMR Expressed in the cytoplasm and nuclei.
Specimen S2 NCC-/-: postnatal; Ednrbtm1Nrd/Ednrbtm1Nrd, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant. Small intestine myenteric plexus. Double labeled: green - Rpsa; red - Elavl3 (assay MGI:7639768) and Elavl4 (assay MGI:7639947).
Structure Cell Type Level Pattern Image Note
TS28: myenteric nerve plexus enteric neuron Present S2-/- merge , S2-/- 37/67-LAMR Decreased expression with altered localization (primarily intracellular).
Specimen S4A: embryonic day 10.5 (more )
Note: Foregut. Double labeled: green - Rpsa; red - Sox10 (assay MGI:7639816).
Structure Cell Type Level Pattern Image Note
TS17: migrating neural crest migratory enteric neural crest cell Present S4A merge , S4A 37/67-LAMR Positive neural crest cells had colonized the proximal 3/4 of the foregut.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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