About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:347585 Leon NY, et al., Y chromosome damage underlies testicular abnormalities in ATR-X syndrome. iScience. 2024 May 17;27(5):109629
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7628677
Gene symbol: Cbx5
Gene name: chromobox 5
Antibody: anti-HP1 alpha (ab77256)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 5 Control: embryonic day 16.5; Atrxtm1Rjg/Y (more )
Note: Double labeled: green - Cbx5; red - Gata4 (assay MGI:7628670).
Structure Cell Type Level Pattern Image Note
TS24: Sertoli cell Sertoli cell Present Regionally restricted 5_Control HP1a , 5_Control (merged) Expression in 79% of Gata4 foci. Expression in highly compacted pericentromeric heterochromatin.
Specimen 5 ScAttrxKO: embryonic day 16.5; Atrxtm1Rjg/Y, Plekha5Tg(AMH-cre)1Flor/0 (more )
Note: Conditional mutant. Double labeled: green - Cbx5; red - Gata4 (assay MGI:7628670).
Structure Cell Type Level Pattern Image Note
TS24: Sertoli cell Sertoli cell Present Regionally restricted 5_ScAtrxKO Hp1a , 5_ScAtrxKO (merged) Expression in Gata4 foci severely reduced or absent. Expression in pericentromeric heterochromatin unaffected compared to control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory