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Gene Expression Data
Assay Details
Assay
Reference: J:146175 Bacon C, et al., Dynamic expression of the Slit-Robo GTPase activating protein genes during development of the murine nervous system. J Comp Neurol. 2009 Mar 10;513(2):224-36
Assay type: RNA in situ
MGI Accession ID: MGI:7621438
Gene symbol: Srgap1
Gene name: SLIT-ROBO Rho GTPase activating protein 1
Probe: srGAP1 cDNA
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen 1A: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: telencephalon Absent 1A
Specimen 1D: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: cortical plate Present 1D
TS21: cerebral cortex intermediate zone Weak 1D
TS21: cortical subplate Weak 1D
Specimen 1G: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: cortical plate Strong 1G
TS24: cerebral cortex intermediate zone Weak 1G
TS24: cerebral cortex ventricular layer Weak 1G
Specimen 1J: postnatal day 7 (more )
Structure Level Pattern Image Note
TS28: cortical layer II Present 1J
TS28: cortical layer III Present 1J
TS28: cortical layer IV Present 1J
TS28: cortical layer V Present 1J
TS28: cortical layer VI Present Scattered 1J
TS28: cortical layer I Absent 1J
Specimen 2A: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: thalamus Present Regionally restricted 2A Expression is in the dorsal thalamus.
Specimen 2D: postnatal day 1 (more )
Structure Level Pattern Image Note
TS27: hippocampus CA3 Strong 2D
TS27: hippocampus Present 2D
TS27: dentate gyrus Weak 2D
TS27: hippocampus CA1 Weak 2D
TS27: dorsal thalamus Weak 2D
TS27: thalamus Weak 2D Expression was weak in the dorsal and ventral thalamus.
Specimen 2G: postnatal day 7 (more )
Structure Level Pattern Image Note
TS28: dentate gyrus Present 2G
TS28: dorsal lateral geniculate nucleus Present 2G
TS28: hippocampus CA1 Present 2G
TS28: hippocampus CA3 Present 2G
TS28: ventral lateral geniculate nucleus Weak 2G
Specimen 3A: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: midbrain roof plate Present Regionally restricted 3A Expression is in the roof of the midbrain in the superior colliculus differentiating zone, and is largely absent from the superior colliculus neuroepithelium.
TS21: cerebellum Absent 3A
Specimen 3A': embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: cerebellum Absent 3A'
Specimen 3D: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: superior colliculus Weak 3D
TS24: cerebellum Weak Regionally restricted 3D Expression is in the cerebellar plate.
TS24: inferior colliculus Weak 3D There is a discrepancy between the table and the text. The text states that expression is present and the table states it is absent.
Specimen 3G: postnatal day 1 (more )
Structure Level Pattern Image Note
TS27: cerebellum Purkinje cell layer Present 3G
TS27: cerebellum external granule cell layer Present 3G
TS27: cerebellum internal granule cell layer Present 3G
TS27: tectum Present Regionally restricted 3G Expression is in a region of the inferior colliculus.
Specimen 3J: postnatal day 7 (more )
Structure Level Pattern Image Note
TS28: cerebellum Purkinje cell layer Strong 3J
TS28: cerebellum external granule cell layer Strong 3J
TS28: cerebellum granule cell layer Strong 3J
TS28: cerebellum molecular layer Absent 3J
Specimen 4A: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: neural tube Present Regionally restricted 4A Expression is in the ventral horns.
TS19: dorsal root ganglion Absent 4A
Specimen 4D: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: spinal cord dorsal horn Present 4D
TS20: spinal cord ventral horn Present 4D
Specimen 4G: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: spinal cord dorsal horn Present 4G
TS21: spinal cord ventral horn Present 4G
Specimen 5A: embryonic day 14.5 (more )
Structure Cell Type Level Pattern Image Note
TS22: main olfactory bulb mitral cell layer Strong 5A
TS22: vomeronasal organ Present 5A
TS22: main olfactory bulb layer neuron Present Scattered 5A Expression is in some scattered neurons of the ganglion layer.
TS22: olfactory epithelium Absent 5A
Specimen 5D: postnatal day 1 (more )
Structure Level Pattern Image Note
TS27: main olfactory bulb mitral cell layer Strong 5D
TS27: main olfactory bulb granule cell layer Present 5D
TS27: olfactory epithelium Absent 5D
Specimen 6A: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: eye Absent 6A
Specimen 6D: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: retina ganglion cell layer Weak 6D
Specimen Table 1 E11.5: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: future spinal cord Present Regionally restricted Expression is in the ventral horn and is absent in the dorsal horn.
TS19: dorsal root ganglion Absent
TS19: nasal pit Absent
TS19: neural tube floor plate Absent
TS19: neural tube roof plate Absent
TS19: retina Absent
TS19: telencephalon Absent
Specimen Table 1 E12.5: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: spinal cord Present Regionally restricted Expression is in the dorsal and ventral horn.
TS20: brain nucleus Present Regionally restricted Expression is in the dorsal lateral geniculate nucleus and is absent in the ventral lateral geniculate nucleus.
TS20: cerebellum primordium Present Regionally restricted Expression is in the cerebellar nuclei differentiating zone.
TS20: cerebral cortex ventricular layer Absent
TS20: cortical preplate Absent
TS20: dorsal root ganglion Absent
TS20: olfactory epithelium Absent
TS20: retina Absent
TS20: spinal cord floor plate Absent
TS20: spinal cord roof plate Absent
TS20: vomeronasal organ Absent
Specimen Table 1 E13.5: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: cerebral cortex intermediate zone Present
TS21: cortical plate Present
TS21: cortical subplate Present
TS21: main olfactory bulb layer Present Regionally restricted Expression is in the mitral layer and is absent in the granule cell layer.
TS21: brain nucleus Present Regionally restricted Expression is in the dorsal lateral geniculate nucleus and ventral lateral geniculate nucleus.
TS21: midbrain roof plate Present Regionally restricted Expression is in the differentiating zone of the superior colliculus.
TS21: spinal cord Present Regionally restricted Expression is in the dorsal and ventral horn.
TS21: cerebral cortex marginal layer Absent
TS21: cerebral cortex ventricular layer Absent
TS21: dorsal root ganglion Absent
TS21: olfactory epithelium Absent
TS21: retina Absent
TS21: spinal cord floor plate Absent
TS21: spinal cord roof plate Absent
TS21: vomeronasal organ Absent
Specimen Table 1 E14.5: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: cerebral cortex intermediate zone Present
TS22: cortical plate Present
TS22: dorsal lateral geniculate nucleus Present
TS22: hippocampus Present
TS22: main olfactory bulb mitral cell layer Present
TS22: retina ganglion cell layer Present
TS22: ventral lateral geniculate nucleus Present
TS22: vomeronasal organ Present
TS22: neural retinal epithelium Present Regionally restricted Expression is in the neuroblastic layer.
TS22: main olfactory bulb layer Present Regionally restricted Expression is in the granule cell layer.
TS22: superior colliculus Present Regionally restricted Expression is in the differentiating zone of the superior colliculus.
TS22: cerebral cortex marginal layer Absent
TS22: cerebral cortex ventricular layer Absent
TS22: cortical subplate Absent
TS22: inferior colliculus Absent
TS22: olfactory epithelium Absent
Specimen Table 1 E16.5: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: cerebral cortex intermediate zone Present
TS24: cerebral cortex ventricular layer Present
TS24: cortical plate Present
TS24: dorsal lateral geniculate nucleus Present
TS24: hippocampus Present
TS24: main olfactory bulb mitral cell layer Present
TS24: main olfactory bulb prospective granule cell layer Present
TS24: retina ganglion cell layer Present
TS24: retina nuclear layer Present
TS24: ventral lateral geniculate nucleus Present
TS24: superior colliculus Present Regionally restricted Expression is in the differentiating zone of the superior colliculus.
TS24: cerebellum Present Regionally restricted Expression is in the cerebellar plate.
TS24: cerebral cortex marginal layer Absent
TS24: cortical subplate Absent
TS24: olfactory epithelium Absent
TS24: vomeronasal organ Absent
TS24: inferior colliculus Absent There is a discrepancy between the table and the text. The text states that expression is present and the table states it is absent.
Specimen Table 1 P1: postnatal day 1 (more )
Structure Level Pattern Image Note
TS27: cerebellum Purkinje cell layer Present
TS27: cerebellum external granule cell layer Present
TS27: cerebellum granule cell layer Present
TS27: cortical layer II Present
TS27: cortical layer III Present
TS27: cortical layer IV Present
TS27: cortical layer V Present
TS27: cortical layer VI Present
TS27: dentate gyrus Present
TS27: dorsal lateral geniculate nucleus Present
TS27: hippocampus CA1 Present
TS27: hippocampus CA3 Present
TS27: main olfactory bulb granule cell layer Present
TS27: main olfactory bulb mitral cell layer Present
TS27: ventral lateral geniculate nucleus Present
TS27: inferior colliculus Present Regionally restricted Expression is in the differentiating zone.
TS27: cerebellum molecular layer Absent
TS27: cerebral cortex ventricular zone Absent
TS27: cortical layer I Absent
TS27: olfactory epithelium Absent
TS27: superior colliculus Absent
TS27: vomeronasal organ Absent
Specimen Table 1 P7: postnatal day 7 (more )
Structure Level Pattern Image Note
TS28: cerebellum Purkinje cell layer Present
TS28: cerebellum external granule cell layer Present
TS28: cerebellum granule cell layer Present
TS28: cortical layer II Present
TS28: cortical layer III Present
TS28: cortical layer IV Present
TS28: cortical layer V Present
TS28: cortical layer VI Present
TS28: dentate gyrus Present
TS28: dorsal lateral geniculate nucleus Present
TS28: hippocampus CA1 Present
TS28: hippocampus CA3 Present
TS28: ventral lateral geniculate nucleus Present
TS28: ventral posterior lateral thalamic nucleus Present
TS28: ventrolateral thalamic nucleus Present
TS28: cerebellum molecular layer Absent
TS28: cerebral cortex ventricular zone Absent
TS28: cortical layer I Absent
TS28: deep cerebellar nucleus Absent
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/28/2024
MGI 6.13 		The Jackson Laboratory